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Hypertension, diabetes, and cardiovascular disease are the main comorbidities, and more than 660,000 Americans have kidney failure. \u03b2<jats:sub>2<\/jats:sub>-Adrenergic receptors (\u03b2<jats:sub>2<\/jats:sub>ARs) have been extensively studied in association with lung and cardiovascular disease, but with limited scope in kidney and renal diseases. \u03b2<jats:sub>2<\/jats:sub>ARs are expressed in multiple parts of the kidney including proximal and distal convoluted tubules, glomeruli, and podocytes. Classical and noncanonical \u03b2<jats:sub>2<\/jats:sub>AR signaling pathways interface with other intracellular mechanisms in the kidney to regulate important cellular functions including renal blood flow, electrolyte balance and salt handling, and tubular function that in turn exert control over critical physiology and pathology such as blood pressure and inflammatory responses. Nephroprotection through activation of \u03b2<jats:sub>2<\/jats:sub>ARs has surfaced as a promising field of investigation; however, there is limited data on the pharmacology and potential side effects of renal \u03b2<jats:sub>2<\/jats:sub>AR modulation. Here, we provide updates on some of the major areas of preclinical kidney research involving \u03b2<jats:sub>2<\/jats:sub>AR signaling that have advanced to describe molecular pathways and identify potential drug targets some of which are currently under clinical development for the treatment of kidney-related diseases. <\/jats:p>","DOI":"10.1152\/ajpregu.00287.2020","type":"journal-article","created":{"date-parts":[[2021,2,10]],"date-time":"2021-02-10T13:00:58Z","timestamp":1612962058000},"page":"R575-R587","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":20,"title":["\u03b2<sub>2<\/sub>-Adrenergic receptor agonism as a therapeutic strategy for kidney disease"],"prefix":"10.1152","volume":"320","author":[{"given":"Ali","family":"Kamiar","sequence":"first","affiliation":[{"name":"Interdisciplinary Stem Cell Institute, University of Miami Leonard M. 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