{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:49:38Z","timestamp":1787017778046,"version":"build-2736575974"},"reference-count":75,"publisher":"American Physiological Society","issue":"3","funder":[{"name":"NIH","award":["HL083192"],"award-info":[{"award-number":["HL083192"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Regulatory, Integrative and Comparative Physiology"],"published-print":{"date-parts":[[2018,3,1]]},"abstract":"<jats:p>\n                    We have addressed the hypothesis that the opposing effects of bronchopulmonary C-fiber activation on cough are attributable to the activation of C-fiber subtypes. Coughing was evoked in anesthetized guinea pigs by citric acid (0.001\u20132 M) applied topically in 100-\u00b5l aliquots to the tracheal mucosa. In control preparations, citric acid evoked 10\u2009\u00b1\u20091 coughs cumulatively. Selective activation of the pulmonary C fibers arising from the nodose ganglia with either aerosols or continuous intravenous infusion of adenosine or the 5-HT\n                    <jats:sub>3<\/jats:sub>\n                    receptor-selective agonist 2-methyl-5-HT nearly abolished coughing evoked subsequently by topical citric acid challenge. Delivering adenosine or 2-methyl-5-HT directly to the tracheal mucosa (where few if any nodose C fibers terminate) was without effect on citric acid-evoked cough. These actions of pulmonary administration of adenosine and 2-methyl-5-HT were accompanied by an increase in respiratory rate, but it is unlikely that the change in respiratory pattern caused the decrease in coughing, as the rapidly adapting receptor stimulant histamine also produced a marked tachypnea but was without effect on cough. In awake guinea pigs, adenosine failed to evoke coughing but reduced coughing induced by the nonselective C-fiber stimulant capsaicin. We conclude that bronchopulmonary C-fiber subtypes in guinea pigs have opposing effects on cough, with airway C fibers arising from the jugular ganglia initiating and\/or sensitizing the cough reflex and the intrapulmonary C fibers arising from the nodose ganglia actively inhibiting cough upon activation.\n                  <\/jats:p>","DOI":"10.1152\/ajpregu.00313.2017","type":"journal-article","created":{"date-parts":[[2017,11,29]],"date-time":"2017-11-29T15:55:17Z","timestamp":1511970917000},"page":"R489-R498","source":"Crossref","is-referenced-by-count":47,"title":["Opposing effects of bronchopulmonary C-fiber subtypes on cough in guinea pigs"],"prefix":"10.1152","volume":"314","author":[{"given":"Yang-Ling","family":"Chou","sequence":"first","affiliation":[{"name":"Johns Hopkins Asthma and Allergy Center, Baltimore, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nanako","family":"Mori","sequence":"additional","affiliation":[{"name":"Johns Hopkins Asthma 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