{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T23:48:12Z","timestamp":1792799292217,"version":"4.5.0"},"reference-count":50,"publisher":"American Physiological Society","issue":"5","funder":[{"name":"Women's Development Council"},{"name":"NeuroDevNet","id":[{"id":"https:\/\/ror.org\/04r0s0t24","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Regulatory, Integrative and Comparative Physiology"],"published-print":{"date-parts":[[2018,5,1]]},"abstract":"<jats:p>We determined the impact of moderate maternal nutrient restriction (MNR) in guinea pigs with fetal growth restriction (FGR) on offspring body and organ weights, hypothesizing that FGR-MNR animals will show catch-up growth but with organ-specific differences. Guinea pig sows were fed ad libitum (Control) or 70% of the control diet from 4 weeks preconception, switching to 90% at midpregnancy (MNR). Control newborns &gt;95 g [appropriate for gestational age (AGA); n = 37] and MNR newborns &lt;85 g (FGR; n = 37) were monitored until neonatal (~25 days) or adult (~110 days) necropsy. Birth weights and body\/organ weights at necropsy were used to calculate absolute and fractional growth rates (FRs). FGR-MNR birth weights were decreased ~32% compared with the AGA-Controls. FGR-MNR neonatal whole body FRs were increased ~36% compared with Controls indicating catch-up growth, with values negatively correlated to birth weights indicating the degree of FGR leads to greater catch-up growth. However, the increase in organ FRs in the FGR-MNR neonates compared with Controls was variable, being similar for the brain and kidneys indicating comparable catch-up growth to that of the whole body and twofold increased for the liver but negligible for the heart indicating markedly increased and absent catch-up growth, respectively. While FGR-MNR body and organ weights were unchanged from the AGA-Controls by adulthood, whole body growth rates were increased. These findings confirm early catch-up growth in FGR-MNR guinea pigs but with organ-specific differences and enhanced growth rates by adulthood, which are likely to have implications for structural alterations and disease risk in later life.<\/jats:p>","DOI":"10.1152\/ajpregu.00317.2017","type":"journal-article","created":{"date-parts":[[2018,1,10]],"date-time":"2018-01-10T14:02:19Z","timestamp":1515592939000},"page":"R647-R654","source":"Crossref","is-referenced-by-count":16,"title":["Maternal nutrient restriction in guinea pigs as an animal model for studying growth-restricted offspring with postnatal catch-up growth"],"prefix":"10.1152","volume":"314","author":[{"given":"Catherine L.","family":"Nevin","sequence":"first","affiliation":[{"name":"Departments of Obstetrics and Gynecology, Physiology and Pharmacology, and Anatomy and Cell Biology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evan","family":"Formosa","sequence":"additional","affiliation":[{"name":"Departments of Obstetrics and Gynecology, Physiology and Pharmacology, and Anatomy and Cell Biology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yohei","family":"Maki","sequence":"additional","affiliation":[{"name":"Departments of Obstetrics and Gynecology, Physiology and Pharmacology, and Anatomy and Cell Biology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brad","family":"Matushewski","sequence":"additional","affiliation":[{"name":"Departments of Obstetrics and Gynecology, Physiology and Pharmacology, and Anatomy and Cell Biology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy R. 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