{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T11:59:01Z","timestamp":1740139141751,"version":"3.37.3"},"reference-count":41,"publisher":"American Physiological Society","issue":"2","funder":[{"DOI":"10.13039\/100000055","name":"HHS | NIH | National Institute on Deafness and Other Communication Disorders","doi-asserted-by":"publisher","award":["RO1DC4607"],"award-info":[{"award-number":["RO1DC4607"]}],"id":[{"id":"10.13039\/100000055","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["American Journal of Physiology-Regulatory, Integrative and Comparative Physiology"],"published-print":{"date-parts":[[2023,8,1]]},"abstract":"<jats:p> Static high magnetic fields (MFs) interact with the vestibular system of humans and rodents. In rats and mice, exposure to MFs causes perturbations such as head movements, circular locomotion, suppressed rearing, nystagmus, and conditioned taste aversion acquisition. To test the role of otoconia, two mutant mouse models were examined, head-tilt Nox3 <jats:sup>het<\/jats:sup> ( het) and tilted Otop1 ( tlt), with mutations, respectively, in Nox3, encoding the NADPH oxidase 3 enzyme, and Otop1, encoding the otopetrin 1 proton channel, which are normally expressed in the otolith organs, and are critical for otoconia formation. Consequently, both mutants show a near complete loss of otoconia in the utricle and saccule, and are nonresponsive to linear acceleration. Mice were exposed to a 14.1 Tesla MF for 30 min. After exposure, locomotor activity, conditioned taste aversion and c-Fos (in het) were assessed. Wild-type mice exposed to the MF showed suppressed rearing, increased latency to rear, locomotor circling, and c-Fos in brainstem nuclei related to vestibular processing (prepositus, spinal vestibular, and supragenual nuclei). Mutant het mice showed no response to the magnet and were similar to sham animals in all assays. Unlike het, tlt mutants exposed to the MF showed significant locomotor circling and suppressed rearing compared with sham controls, although they failed to acquire a taste aversion. The residual responsiveness of tlt versus het mice might reflect a greater semicircular deficit in het mice. These results demonstrate the necessity of the otoconia for the full effect of exposure to high MFs, but also suggest a semicircular contribution. <\/jats:p>","DOI":"10.1152\/ajpregu.00317.2022","type":"journal-article","created":{"date-parts":[[2023,6,12]],"date-time":"2023-06-12T12:43:11Z","timestamp":1686573791000},"page":"R181-R192","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Behavioral and neural responses to high-strength magnetic fields are reduced in otolith mutant mice"],"prefix":"10.1152","volume":"325","author":[{"given":"Jason M.","family":"Cote","sequence":"first","affiliation":[{"name":"Department of Biological Science, Florida State University, Tallahassee, Florida, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alison","family":"Hood","sequence":"additional","affiliation":[{"name":"Department of Biological Science, Florida State University, Tallahassee, 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