{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T23:32:36Z","timestamp":1790811156521,"version":"4.1.0"},"reference-count":28,"publisher":"American Physiological Society","issue":"2","funder":[{"DOI":"10.13039\/100000968","name":"American Heart Association (AHA)","doi-asserted-by":"publisher","award":["14SDG18560022"],"award-info":[{"award-number":["14SDG18560022"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"HHS | National Institutes of Health (NIH)","doi-asserted-by":"publisher","award":["1F31HL136067-01"],"award-info":[{"award-number":["1F31HL136067-01"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Regulatory, Integrative and Comparative Physiology"],"published-print":{"date-parts":[[2018,2,1]]},"abstract":"<jats:p>Sudden infant death syndrome (SIDS) is associated with serotonin (5-HT) neuron abnormalities. There is evidence of autonomic dysfunction during sleep in infants eventually succumbing to SIDS, as well as cardiovascular collapse before death. Neonatal rodents deficient in central 5-HT display hypotension and bradycardia. We hypothesized that central 5-HT reduces cardiac vagal tone and increases sympathetic vascular tone and, given the firing pattern of 5-HT neurons, that these effects are greater in quiet sleep (QS) than in active sleep (AS). We tested these hypotheses using 2-wk-old male and female rat pups lacking tryptophan hydroxylase-2 ( TPH2<jats:sup>\u2212\/\u2212<\/jats:sup>) and wild-type (WT) littermates. Arterial blood pressure (ABP) and heart rate (HR) were measured over 3 h during periods of QS and AS. We also gave atropine or atenolol (each 1 mg\/kg iv), or phentolamine (5, 50, and 500 \u03bcg\/kg iv) to separate groups to assess the effects 5-HT deficiency on autonomic tone to the heart or sympathetic vascular tone, respectively. Compared with WT, male and female TPH2<jats:sup>\u2212\/\u2212<\/jats:sup>pups had reduced ABP in QS but not in AS. Atropine induced a greater HR increase in female TPH2<jats:sup>\u2212\/\u2212<\/jats:sup>than in female WT pups, an effect absent in male TPH2<jats:sup>\u2212\/\u2212<\/jats:sup>pups. Both genotypes experienced the same atenolol-induced drop in HR. In males only, phentolamine induced a smaller decrease in the ABP of TPH2<jats:sup>\u2212\/\u2212<\/jats:sup>pups compared with WT. These data suggest that central 5-HT maintains ABP in QS, and HR in both states. In males, central 5-HT facilitates sympathetic vascular tone, and in females it reduces cardiac vagal drive.<\/jats:p>","DOI":"10.1152\/ajpregu.00321.2017","type":"journal-article","created":{"date-parts":[[2017,10,18]],"date-time":"2017-10-18T17:35:33Z","timestamp":1508348133000},"page":"R313-R321","source":"Crossref","is-referenced-by-count":13,"title":["Central serotonin and the control of arterial blood pressure and heart rate in infant rats: influence of sleep state and sex"],"prefix":"10.1152","volume":"314","author":[{"given":"Jennifer L.","family":"Magnusson","sequence":"first","affiliation":[{"name":"Department of Biomedical Sciences, College of Veterinary Medicine, University of Missouri, Columbia, Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4100-8856","authenticated-orcid":false,"given":"Kevin J.","family":"Cummings","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, College of Veterinary Medicine, University of Missouri, Columbia, Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0810793106"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1113\/expphysiol.2012.069377"},{"key":"B3","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/S0022-3565(25)12828-0","volume":"277","author":"Costarella CE","year":"1996","journal-title":"J Pharmacol Exp Ther"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00122.2009"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00110.2010"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00506.2011"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1016\/j.resp.2011.09.005"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1210\/endo-97-4-898"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1042\/CS20150654"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.01015.2015"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.pathol.4.110807.092322"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra0803836"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00576.2010"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00241.2015"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(76)90480-7"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1998.85.1.84"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1021\/cn300165x"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-199903000-00010"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1016\/S0361-9230(01)00612-8"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0702183"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/11.5.413"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1016\/0378-3782(89)90077-7"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-199206000-00014"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2013.04.001"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.10287"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(81)90146-9"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00970.2013"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00439.2017"}],"container-title":["American Journal of Physiology-Regulatory, Integrative and Comparative Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/ajpregu.00321.2017","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,26]],"date-time":"2025-06-26T15:16:28Z","timestamp":1750950988000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/ajpregu.00321.2017"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2,1]]},"references-count":28,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2018,2,1]]}},"alternative-id":["10.1152\/ajpregu.00321.2017"],"URL":"https:\/\/doi.org\/10.1152\/ajpregu.00321.2017","relation":{},"ISSN":["0363-6119","1522-1490"],"issn-type":[{"value":"0363-6119","type":"print"},{"value":"1522-1490","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,2,1]]}}}