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In addition to providing a general indication of whether a variable of interest alters thermoregulatory control, this relationship is often used to determine how this alteration may occur. This latter interpretation relies upon two parameters of the thermoeffector output-body temperature relationship: the onset threshold and thermosensitivity. Traditionally, changes in the onset threshold and thermosensitivity are interpreted as \u201ccentral\u201d or \u201cperipheral\u201d modulation of thermoregulatory control, respectively. This mini-review revisits the origins of the thermoeffector output-body temperature relationship and its use to interpret \u201ccentral\u201d or \u201cperipheral\u201d modulation of thermoregulatory control. Against this background, we discuss the strengths and weaknesses of this approach and highlight that \u201ccentral\u201d thermoregulatory control reflects the neural control of body temperature whereas \u201cperipheral\u201d thermoregulatory control reflects properties specific to the thermoeffector organs. We highlight studies that employed more direct approaches to investigate the neural control of body temperature and peripheral properties of thermoeffector organs. We conclude by encouraging future investigations interested in studying thermoregulatory control to more directly investigate the component of the thermoeffector loop under investigation. <\/jats:p><jats:p> heat; human; skin blood flow; sweat; thermoregulatory <\/jats:p>","DOI":"10.1152\/ajpregu.00321.2020","type":"journal-article","created":{"date-parts":[[2021,6,2]],"date-time":"2021-06-02T12:02:21Z","timestamp":1622635341000},"page":"R91-R99","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":15,"title":["Revisiting the evaluation of central versus peripheral thermoregulatory control in humans"],"prefix":"10.1152","volume":"321","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4894-9552","authenticated-orcid":true,"given":"Nicholas","family":"Ravanelli","sequence":"first","affiliation":[{"name":"School of Kinesiology, Lakehead University, Ontario, 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