{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T13:36:40Z","timestamp":1791121000649,"version":"4.1.0"},"reference-count":48,"publisher":"American Physiological Society","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Regulatory, Integrative and Comparative Physiology"],"published-print":{"date-parts":[[2005,1]]},"abstract":"<jats:p>Hydrogen sulfide (H<jats:sub>2<\/jats:sub>S) is a recently identified endogenous vasodilator in mammals. In steelhead\/rainbow trout ( Oncorhynchus mykiss, Osteichthyes), H<jats:sub>2<\/jats:sub>S produces both dose-dependent dilation and a unique dose-dependent constriction. In this study, we examined H<jats:sub>2<\/jats:sub>S vasoactivity in all vertebrate classes to determine whether H<jats:sub>2<\/jats:sub>S is universally vasoactive and to identify phylogenetic and\/or environmental trends. H<jats:sub>2<\/jats:sub>S was generated from NaHS and examined in unstimulated and precontracted systemic and, when applicable, pulmonary arteries (PA) from Pacific hagfish ( Eptatretus stouti, Agnatha), sea lamprey ( Petromyzon marinus, Agnatha), sandbar shark ( Carcharhinus milberti, Chondrichthyes), marine toad ( Bufo marinus, Amphibia), American alligator ( Alligator mississippiensis, Reptilia), Pekin duck ( Anas platyrhynchos domesticus, Aves), and white rat ( Rattus rattus, Mammalia). In otherwise unstimulated vessels, NaHS produced 1) a dose-dependent relaxation in Pacific hagfish dorsal aorta; 2) a dose-dependent contraction in sea lamprey dorsal aorta, marine toad aorta, alligator aorta and PA, duck aorta, and rat thoracic aorta; 3) a threshold relaxation in shark ventral aorta, dorsal aorta, and afferent branchial artery; and 4) a multiphasic contraction-relaxation-contraction in the marine toad PA, duck PA, and rat PA. Precontraction of these vessels with another agonist did not affect the general pattern of NaHS vasoactivity with the exception of the rat aorta, where relaxation was now dominant. These results show that H<jats:sub>2<\/jats:sub>S is a phylogenetically ancient and versatile vasoregulatory molecule that appears to have been opportunistically engaged to suit both organ-specific and species-specific homeostatic requirements.<\/jats:p>","DOI":"10.1152\/ajpregu.00324.2004","type":"journal-article","created":{"date-parts":[[2004,9,3]],"date-time":"2004-09-03T00:24:16Z","timestamp":1094171056000},"page":"R243-R252","source":"Crossref","is-referenced-by-count":79,"title":["Vertebrate phylogeny of hydrogen sulfide vasoactivity"],"prefix":"10.1152","volume":"288","author":[{"given":"Ryan A.","family":"Dombkowski","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Russell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexis A.","family":"Schulman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meredith M.","family":"Doellman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth R.","family":"Olson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"R1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.16-03-01066.1996"},{"key":"R2","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.86.3.355"},{"key":"R3","doi-asserted-by":"publisher","DOI":"10.1016\/0166-445X(92)90015-F"},{"key":"R4","unstructured":"Boutilier RG, Heming TA, and Iwama GK.Physiochemical parameters for use in fish respiratory physiology. In:Gills. Fish Physiology, edited by Hoar WS and Randall DJ. Orlando, FL: Academic, 1984,vol. X, part A, p. 401\u2013430."},{"key":"R5","doi-asserted-by":"publisher","DOI":"10.1021\/ac50011a024"},{"key":"R6","doi-asserted-by":"publisher","DOI":"10.1007\/BF00369516"},{"key":"R7","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00419.2003"},{"key":"R8","doi-asserted-by":"publisher","DOI":"10.1086\/319308"},{"key":"R9","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.1998.274.4.R1050"},{"key":"R10","doi-asserted-by":"publisher","DOI":"10.1002\/1097-010X(20010415\/30)289:5<273::AID-JEZ1>3.0.CO;2-L"},{"key":"R11","doi-asserted-by":"publisher","DOI":"10.1139\/z95-223"},{"key":"R12","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.2000.279.6.R2200"},{"key":"R13","doi-asserted-by":"publisher","DOI":"10.1038\/288373a0"},{"key":"R14","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2003.11.130"},{"key":"R15","doi-asserted-by":"publisher","DOI":"10.1093\/occmed\/46.5.367"},{"key":"R16","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1997.6878"},{"key":"R17","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.1995.64"},{"key":"R18","doi-asserted-by":"publisher","DOI":"10.1085\/jgp.19.3.397"},{"key":"R19","doi-asserted-by":"publisher","DOI":"10.1242\/jeb.00883"},{"key":"R20","doi-asserted-by":"publisher","DOI":"10.1016\/0041-008X(90)90321-K"},{"key":"R21","doi-asserted-by":"publisher","DOI":"10.3109\/01480548809018109"},{"key":"R22","doi-asserted-by":"crossref","unstructured":"Miller VMand Vanhoutte PM.Endothelium-dependent responses in isolated blood vessels of lower vertebrates.Blood Vessels23: 225\u2013235, 1986.","DOI":"10.1159\/000158643"},{"key":"R23","unstructured":"Mustafa Tand Agnisola C.Vasactivity of adenosine in the trout (Oncorhynchus mykiss) coronary system: involvement of nitric oxide and interaction with noradrenaline.J Exp Biol201: 3075\u20133083, 1998."},{"key":"R24","doi-asserted-by":"publisher","DOI":"10.1139\/o82-076"},{"key":"R25","doi-asserted-by":"crossref","unstructured":"Nicholson RA, Roth SH, Zhang A, Zheng J, Brookes J, Skrajny B, and Bennington R.Inhibition of respiratory and bioenergetic mechanisms by hydrogen sulfide in mammalian brain.J Toxicol Environ Health54: 491\u2013507, 1988.","DOI":"10.1080\/009841098158773"},{"key":"R26","unstructured":"Olson KR.Vascular actions of hydrogen sulfide in nonmammalian vertebrates.Antioxid Redox SignalIn press."},{"key":"R27","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.1997.273.2.R527"},{"key":"R28","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-010X(20000501)286:6<606::AID-JEZ7>3.0.CO;2-V"},{"key":"R29","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.2001.280.1.R198"},{"key":"R30","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.1991.260.5.R925"},{"key":"R31","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.pa.32.040192.000545"},{"key":"R32","doi-asserted-by":"crossref","unstructured":"Schwerte T, Holmgren S, and Pelster B.Vasodilation of swimbladder vessels in the European eel (Anguilla anguilla) induced by vasoactive intestinal peptide, nitric oxide, adenosine and protons.J Exp Biol202: 1005\u20131013, 1999.","DOI":"10.1242\/jeb.202.8.1005"},{"key":"R33","unstructured":"Shi L, Du J, Qi J, Wei B, Tang C, and Tang X.Effects of high pulmonary blood flow on pulmonary vasculature structure and the gene expression of cystathionine-\u03b3-lyase.Beijing Da Xue Xue Bao35: 566\u2013570, 2003."},{"key":"R34","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0773.2001.d01-104.x"},{"key":"R35","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.1990.258.6.R1402"},{"key":"R36","doi-asserted-by":"publisher","DOI":"10.1086\/317732"},{"key":"R37","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(95)11927-O"},{"key":"R38","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0704858"},{"key":"R39","doi-asserted-by":"publisher","DOI":"10.1016\/S0300-483X(03)00079-9"},{"key":"R40","doi-asserted-by":"crossref","unstructured":"Torrans ELand Clemens HP.Physiological and biochemical effects of acute exposure of fish to hydrogen sulfide.Comp Biochem Physiol71C: 183\u2013190, 1982.","DOI":"10.1016\/0306-4492(82)90034-X"},{"key":"R41","doi-asserted-by":"publisher","DOI":"10.1096\/fj.02-0211hyp"},{"key":"R42","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1997.62"},{"key":"R43","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2003.11.081"},{"key":"R44","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-291X(03)00256-0"},{"key":"R45","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00013.2002"},{"key":"R46","doi-asserted-by":"publisher","DOI":"10.1139\/y03-077"},{"key":"R47","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/20.21.6008"},{"key":"R48","doi-asserted-by":"publisher","DOI":"10.1097\/00004872-200310000-00017"}],"container-title":["American Journal of Physiology-Regulatory, Integrative and Comparative Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/ajpregu.00324.2004","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,6,25]],"date-time":"2021-06-25T12:29:37Z","timestamp":1624624177000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/ajpregu.00324.2004"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,1]]},"references-count":48,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2005,1]]}},"alternative-id":["10.1152\/ajpregu.00324.2004"],"URL":"https:\/\/doi.org\/10.1152\/ajpregu.00324.2004","relation":{},"ISSN":["0363-6119","1522-1490"],"issn-type":[{"value":"0363-6119","type":"print"},{"value":"1522-1490","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,1]]}}}