{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T14:21:10Z","timestamp":1790864470696,"version":"4.1.0"},"reference-count":41,"publisher":"American Physiological Society","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Regulatory, Integrative and Comparative Physiology"],"published-print":{"date-parts":[[2008,4]]},"abstract":"<jats:p>\n                    Sympathetic vasoconstriction of cerebral vessels has been proposed to be a protective mechanism for the brain, limiting cerebral perfusion and microcirculatory pressure during transient increases in arterial pressure. To furnish direct neural evidence for this proposition, we aimed to develop a method for recording cerebral sympathetic nerve activity (SNA) from the superior cervical ganglion (SCG). We hypothesized that SNA recorded from the SCG increases during imposed hypertension, but not during hypotension. Lambs ( n = 11) were anesthetized (\u03b1-chloralose, 20 mg\u00b7kg\n                    <jats:sup>\u22121<\/jats:sup>\n                    \u00b7h\n                    <jats:sup>\u22121<\/jats:sup>\n                    ) and ventilated. SNA was measured using 25-\u03bcm tungsten microelectrodes inserted into the SCG. Arterial blood pressure (AP) was pharmacologically raised (adrenaline, phenylephrine, or ANG II, 1\u201350 \u03bcg\/kg iv), mechanically raised (intravascular balloon in the thoracic aorta), or lowered (sodium nitroprusside, 1\u201350 \u03bcg\/kg iv). In response to adrenaline ( n = 10), mean AP increased 135 \u00b1 10% from baseline (mean \u00b1 SE), and the RMS value of SNA (Square Root of the Mean of the Squares, SNA\n                    <jats:sub>RMS<\/jats:sub>\n                    ) increased 255 \u00b1 120%. In response to mechanically induced hypertension, mean AP increased 43 \u00b1 3%, and SNA\n                    <jats:sub>RMS<\/jats:sub>\n                    increased 53 \u00b1 13%. Generally, (9 of 10 animals), SNA\n                    <jats:sub>RMS<\/jats:sub>\n                    did not increase, as AP was lowered with sodium nitroprusside. Using a new model for direct recording of cerebral SNA from the SCG, we have demonstrated that SNA increases in response to large induced rises, but not falls, in AP. These findings furnish direct support for the proposed protective role for sympathetic nerves in the cerebral circulation.\n                  <\/jats:p>","DOI":"10.1152\/ajpregu.00332.2007","type":"journal-article","created":{"date-parts":[[2008,1,23]],"date-time":"2008-01-23T20:34:57Z","timestamp":1201120497000},"page":"R1255-R1261","source":"Crossref","is-referenced-by-count":134,"title":["Sympathetic nerve activity in the superior cervical ganglia increases in response to imposed increases in arterial pressure"],"prefix":"10.1152","volume":"294","author":[{"given":"Priscila A.","family":"Cassaglia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert I.","family":"Griffiths","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrian M.","family":"Walker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"R1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(86)90293-9"},{"key":"R2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-1716.1983.tb07330.x"},{"key":"R3","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-199811000-00016"},{"key":"R4","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-1716.1976.tb10176.x"},{"key":"R5","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901850211"},{"key":"R6","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.46.5.696"},{"key":"R7","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-198511000-00020"},{"key":"R8","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(87)90942-5"},{"key":"R9","doi-asserted-by":"publisher","DOI":"10.1159\/000027536"},{"key":"R10","unstructured":"Edvinsson L\n                      , Hamel E.\n                      Perivascular nerves in brain vessels. 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