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Eight weeks later, nonexcised pads of lipectomized mice were increased but total carcass fat was lower than in sham-operated ob\/ob mice. In experiment 2, ob\/ob mice, wild-type mice, and two db\/db mutants, C57BL\/6J db<jats:sup>Lepr<\/jats:sup>\/db<jats:sup>Lepr<\/jats:sup>(BL\/6J) mice possessing short-form and circulating leptin receptors and C57BL\/6J db<jats:sup>3J<\/jats:sup>\/db<jats:sup>3J<\/jats:sup>(BL\/3J) mice expressing only circulating receptors, were lipectomized or sham operated. Sixteen weeks later, body mass and carcass lipid were not different between sham and lipectomized ob\/ob mice, wild-type mice, or BL\/6J db\/db mice, whereas there was incomplete (decreased carcass fat) but suggestive recovery (increased retroperitoneal fat mass and cell number) in lipectomized BL\/3J db\/db mice. 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