{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T13:39:15Z","timestamp":1790257155074,"version":"4.1.0"},"reference-count":45,"publisher":"American Physiological Society","issue":"5","funder":[{"name":"Manatu Hauora | Health Research Council of New Zealand (HRC)","award":["12\/613 and 14\/216"],"award-info":[{"award-number":["12\/613 and 14\/216"]}]},{"DOI":"10.13039\/501100001511","name":"Auckland Medical Research Foundation (AMRF)","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001511","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Department of Health, Australian Government | National Health and Medical Research Council (NHMRC)","award":["1090890"],"award-info":[{"award-number":["1090890"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Regulatory, Integrative and Comparative Physiology"],"published-print":{"date-parts":[[2016,11,1]]},"abstract":"<jats:p> The role of cholinergic and \u03b2-adrenergic activity in mediating fetal cardiovascular recovery from brief repeated episodes of asphyxia, consistent with established labor, remains unclear. In this study, we tested the effect of cholinergic and \u03b2-adrenergic blockade on the fetal chemoreflex and fetal heart rate (FHR) overshoot responses during brief repeated asphyxia at rates consistent with early or active labor. Chronically instrumented fetal sheep at 0.85 of gestation received either intravenous atropine sulfate (cholinergic blockade; n = 7) or vehicle ( n = 8) followed by 3 \u00d7 1-min umbilical cord occlusions repeated every 5 min (1:5; consistent with early labor), or intravenous propranolol hydrochloride (\u03b2-adrenergic blockade; n = 8) or vehicle ( n = 6) followed by 3 \u00d7 2-min occlusions repeated every 5 min (2:5; consistent with active labor). In vehicle controls, 1:5 occlusions were associated with rapid and sustained FHR decelerations followed by rapid return of FHR to baseline values after release of the occlusion. Cholinergic blockade abolished FHR decelerations during occlusions and caused FHR overshoot after release of the occlusion ( P &lt; 0.05 vs. control 1:5). In vehicle controls, 2:5 occlusions caused rapid and sustained FHR decelerations followed by FHR overshoot after release of the occlusion. \u03b2-adrenergic blockade was associated with greater reduction in FHR during occlusions and attenuated FHR overshoot ( P &lt; 0.05 vs. control 2:5). These data demonstrate that the FHR overshoot pattern after asphyxia is mediated by a combination of attenuated parasympathetic activity and increased \u03b2-adrenergic stimulation of the fetal heart. <\/jats:p>","DOI":"10.1152\/ajpregu.00340.2016","type":"journal-article","created":{"date-parts":[[2016,9,21]],"date-time":"2016-09-21T23:19:38Z","timestamp":1474499978000},"page":"R949-R956","source":"Crossref","is-referenced-by-count":22,"title":["Cholinergic and \u03b2-adrenergic control of cardiovascular reflex responses to brief repeated asphyxia in term-equivalent fetal sheep"],"prefix":"10.1152","volume":"311","author":[{"given":"Robert","family":"Galinsky","sequence":"first","affiliation":[{"name":"Department of Physiology, The University of Auckland, Auckland, New Zealand; and"},{"name":"The Ritchie Centre, Hudson Institute of Medical Research, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher 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