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Male OZRs also have diminished baroreflex-mediated activation of nucleus tractus solitarius (NTS) and bradycardia, which are improved by correcting their hyperglycemia. Conversely, 3-mo-old female OZRs and lean Zucker rats (LZRs) have equivalent baroreflex-mediated bradycardia that is impaired in 6-mo-old OZRs. We hypothesized that 3-mo-old female OZRs maintain NTS activation and baroreflexes coincident with glycemic control. We also hypothesized that 6-mo-old female OZRs develop impaired baroreflexes with hyperglycemia and diminished NTS activation. In 12- to 16-wk-old females, sympathetic nerve activity (SNA) and arterial pressure (AP) were higher in OZRs than LZRs. However, baroreflex-mediated inhibition of SNA and bradycardia were equivalent in female OZRs and LZRs. Unlike deficits in male OZRs, female OZRs and LZRs had no differences in phenylephrine-induced c-Fos expression in NTS or decreases in SNA and AP evoked by glutamate into NTS. Compared with hyperglycemia in male OZRs (217.9\u2009\u00b1\u200934.4\u2009mg\/dL), female OZRs had normal fed blood glucose levels (108.2\u2009\u00b1\u20091.6\u2009mg\/dL in LZRs and 113.6\u2009\u00b1\u20093.5\u2009mg\/dL in OZRs) with emerging glucose intolerance. Conscious 24- to 27-wk-old female OZRs had impaired baroreflex-mediated bradycardia, but fed blood glucose was modestly elevated (124.2\u2009\u00b1\u20095.2\u2009mg\/dL) and phenylephrine-induced c-Fos expression in NTS was comparable to LZRs. These data suggest that better glycemic control in 3-mo-old female OZRs prevents diminished NTS activation and baroreflexes, supporting the notion that hyperglycemia impairs these responses in male OZRs. However, 6-mo-old female OZRs had impaired baroreflex efficacy without diminished NTS activation or pronounced hyperglycemia, suggesting baroreflex deficits develop by different mechanisms in female and male OZRs. <\/jats:p>","DOI":"10.1152\/ajpregu.00341.2020","type":"journal-article","created":{"date-parts":[[2021,5,12]],"date-time":"2021-05-12T13:22:23Z","timestamp":1620825743000},"page":"R62-R78","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":6,"title":["Preserved glycemic control and baroreflex efficacy in young adult hypertensive female obese Zucker rats"],"prefix":"10.1152","volume":"321","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5181-6515","authenticated-orcid":true,"given":"Parul","family":"Chaudhary","sequence":"first","affiliation":[{"name":"Department of Physiology and Anatomy, University of North Texas Health Science Center, Fort Worth, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paromita","family":"Das-Earl","sequence":"additional","affiliation":[{"name":"Department of Physiology and Anatomy, University of North Texas Health Science Center, Fort Worth, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0069-2847","authenticated-orcid":true,"given":"Ann M.","family":"Schreihofer","sequence":"additional","affiliation":[{"name":"Department of Physiology and Anatomy, University of North Texas Health Science Center, Fort Worth, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","volume-title":"National Center for Health Statistics (US). 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