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Frequency-dependent erectile responses to CN stimulations were reduced in SHR. Phenylephrine induced lower corporal contractions in SHR although pD<jats:sub>2<\/jats:sub>values were similar to WKY. Endothelium-dependent relaxations to ACh were impaired significantly in SHR, and indomethacin improved these relaxations in both WKY and SHR, the latter thus reaching values similar to WKY. Corporal relaxations to sodium nitroprusside were enhanced in SHR. Thus a dysfunctional \u03b1-adrenergic contraction of the corporal smooth muscle, an increased cyclooxygenase-dependent constrictor tone, and\/or a defect in endothelium-dependent reactivity are associated with the altered erectile mechanisms in SHR. Drugs targeting endothelial dysfunction may delay the occurrence of ED as a complication of hypertension.<\/jats:p>","DOI":"10.1152\/ajpregu.00349.2002","type":"journal-article","created":{"date-parts":[[2015,3,3]],"date-time":"2015-03-03T20:27:41Z","timestamp":1425414461000},"page":"R682-R688","source":"Crossref","is-referenced-by-count":60,"title":["Erectile dysfunction in spontaneously hypertensive rats: pathophysiological mechanisms"],"prefix":"10.1152","volume":"284","author":[{"given":"Delphine","family":"Behr-Roussel","sequence":"first","affiliation":[{"name":"Pelvipharm, Domaine Centre National de Recherche Scientifique, 91190 Gif sur Yvette;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Chamiot-Clerc","sequence":"additional","affiliation":[{"name":"Pelvipharm, Domaine Centre National de Recherche Scientifique, 91190 Gif sur Yvette;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacques","family":"Bernabe","sequence":"additional","affiliation":[{"name":"Pelvipharm, Domaine Centre National de Recherche Scientifique, 91190 Gif sur Yvette;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katell","family":"Mevel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Alexandre","sequence":"additional","affiliation":[{"name":"Pelvipharm, Domaine Centre National de Recherche Scientifique, 91190 Gif sur Yvette;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel E.","family":"Safar","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Broussais Hospital, 75014 Paris; 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