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Epidemiological evidence describes an association between a history of preeclampsia and increased risk for cardiovascular disease in later life; however, the mechanism(s) driving this relationship are unclear. Our study aims to leverage a novel preeclampsia-like mouse model, the C1q<jats:sup>\u2212\/\u2212<\/jats:sup> model, to help elucidate the acute and persistent vascular changes during and following a preeclampsia-like pregnancy. Female C57BL\/6J mice were mated to C1q<jats:sup>\u2212\/\u2212<\/jats:sup> male mice to model a preeclampsia-like pregnancy (\u201cPE-like\u201d), and the maternal cardiovascular phenotype (blood pressure, renal function, systemic glycocalyx, and ex vivo vascular function) was assessed in late pregnancy and postpartum at 6 and 10 mo of age. Uncomplicated, normotensive pregnancies (female C57BL\/6J bred to male C57BL\/6J mice) served as age-matched controls. In pregnancy, PE-like dams exhibited increased systolic and diastolic pressure during mid- and late gestation, renal dysfunction, fetal growth restriction, and reduced placental efficiency. Ex vivo wire myography studies of mesenteric arteries revealed severe pregnancy-specific endothelial-dependent and -independent vascular dysfunction. At 3 and 7 mo postpartum (6 and 10 mo old, respectively), hypertension resolved in PE-like dams, whereas mild vascular dysfunction persisted at 3 mo postpartum. In conclusion, the female C57BL\/6J-by-male C57BL\/6J C1q<jats:sup>\u2212\/\u2212<\/jats:sup> model recapitulates many aspects of the human preeclampsia syndrome in a low-risk, wild-type female mouse. The pregnancy-specific phenotype results in systemic maternal endothelial-dependent and -independent vascular dysfunction that persists postpartum. <\/jats:p>","DOI":"10.1152\/ajpregu.00353.2019","type":"journal-article","created":{"date-parts":[[2020,5,6]],"date-time":"2020-05-06T16:05:46Z","timestamp":1588781146000},"page":"R1047-R1057","source":"Crossref","is-referenced-by-count":23,"title":["Paternal deficiency of complement component C1q leads to a preeclampsia-like pregnancy in wild-type female mice and vascular adaptations postpartum"],"prefix":"10.1152","volume":"318","author":[{"given":"Elizabeth F.","family":"Sutton","sequence":"first","affiliation":[{"name":"Magee-Womens Research Institute, Pittsburgh, Pennsylvania"},{"name":"Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh, Pittsburgh, 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