{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T15:03:50Z","timestamp":1792249430869,"version":"4.4.0"},"reference-count":38,"publisher":"American Physiological Society","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Regulatory, Integrative and Comparative Physiology"],"published-print":{"date-parts":[[2007,6]]},"abstract":"<jats:p>This experiment tested effects of human eye pigmentation depending on the ethnicity on suppression of nocturnal melatonin secretion by light. Ten healthy Caucasian males with blue, green, or light brown irises (light-eyed Caucasians) and 11 Asian males with dark brown irises (dark-eyed Asians) volunteered to participate in the study. The mean ages of the light-eyed Caucasians and dark-eyed Asians were 26.4 \u00b1 3.2 and 25.3 \u00b1 5.7 years, respectively. The subjects were exposed to light (1,000 lux) for 2 h at night. The starting time of exposure was set to 2 h before the time of peak salivary melatonin concentration of each subject, which was determined in a preliminary experiment. Salivary melatonin concentration and pupil size were measured before exposure to light and during exposure to light. The percentage of suppression of melatonin secretion by light was calculated. The percentage of suppression of melatonin secretion 2 h after the start of light exposure was significantly larger in light-eyed Caucasians (88.9 \u00b1 4.2%) than in dark-eyed Asians (73.4 \u00b1 20.0%) ( P &lt; 0.01). No significant difference was found between pupil sizes in light-eyed Caucasians and dark-eyed Asians. These results suggest that sensitivity of melatonin to light suppression is influenced by eye pigmentation and\/or ethnicity.<\/jats:p>","DOI":"10.1152\/ajpregu.00355.2006","type":"journal-article","created":{"date-parts":[[2007,3,2]],"date-time":"2007-03-02T04:13:51Z","timestamp":1172808831000},"page":"R2352-R2356","source":"Crossref","is-referenced-by-count":69,"title":["Influence of eye colors of Caucasians and Asians on suppression of melatonin secretion by light"],"prefix":"10.1152","volume":"292","author":[{"given":"Shigekazu","family":"Higuchi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yutaka","family":"Motohashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keita","family":"Ishibashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takafumi","family":"Maeda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"R1","doi-asserted-by":"publisher","DOI":"10.1081\/CBI-100103190"},{"key":"R2","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3940(98)00548-5"},{"key":"R3","unstructured":"Beall C, Steegmann AT Jr.Human adaptation to climate: temperature, ultraviolet radiation, and altitude. 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