{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T06:19:45Z","timestamp":1778825985839,"version":"3.51.4"},"reference-count":50,"publisher":"American Physiological Society","issue":"6","funder":[{"DOI":"10.13039\/100000968","name":"American Heart Association (AHA)","doi-asserted-by":"publisher","award":["15GRNT24480051"],"award-info":[{"award-number":["15GRNT24480051"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"HHS | NIH | National Heart, Lung, and Blood Institute (NHBLI)","doi-asserted-by":"publisher","award":["P01 HL096570"],"award-info":[{"award-number":["P01 HL096570"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"HHS | NIH | National Center for Advancing Translational Sciences (NCATS)","doi-asserted-by":"publisher","award":["UL1 TR000127"],"award-info":[{"award-number":["UL1 TR000127"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"HHS | NIH | National Center for Advancing Translational Sciences (NCATS)","doi-asserted-by":"publisher","award":["UL1 TR002014"],"award-info":[{"award-number":["UL1 TR002014"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Regulatory, Integrative and Comparative Physiology"],"published-print":{"date-parts":[[2017,6,1]]},"abstract":"<jats:p> Heat stress evokes significant increases in muscle sympathetic nerve activity (MSNA) in healthy individuals. The MSNA response to heat stress in chronic heart failure (CHF) is unknown. We hypothesized that the MSNA response to heat stress is attenuated in CHF. Passive whole body heating was applied with water-perfused suits in 13 patients (61\u2009\u00b1\u20092 yr) with stable class II-III CHF, 12 age-matched (62\u2009\u00b1\u20092 yr) healthy subjects, and 14 young (24\u2009\u00b1\u20091 yr) healthy subjects. Mild heating (i.e., increases in skin temperature \u0394Tsk ~2\u20134\u00b0C, internal temperature \u0394Tcore &lt;0.3\u00b0C) significantly decreased MSNA in CHF patients; however, it did not significantly alter the MSNA in the age-matched and young healthy subjects. Heat stress (i.e., \u0394Tsk ~4\u00b0C and \u0394Tcore ~0.6\u00b0C) raised MSNA in the age-matched (32.9\u2009\u00b1\u20093.2 to 45.6\u2009\u00b1\u20094.2 bursts\/min; P &lt; 0.001) and young (14.3\u2009\u00b1\u20091.7 to 26.3\u2009\u00b1\u20092.4 bursts\/min; P &lt; 0.001) controls, but not in CHF (46.2\u2009\u00b1\u20095.3 to 50.5\u2009\u00b1\u20095.3 bursts\/min; P = 0.06). The MSNA increase by the heat stress in CHF (\u03944.2\u2009\u00b1\u20092.0 bursts\/min) was significantly less than those seen in the age-matched (\u039412.8\u2009\u00b1\u20091.7 bursts\/min, P &lt; 0.05) and young (\u039412.0\u2009\u00b1\u20092.7 bursts\/min, P &lt; 0.05) control groups. These data suggest that the MSNA response to heat stress is attenuated in CHF patients. We speculate that the attenuated MSNA response to heat stress may contribute to impaired cardiovascular adjustments in CHF in a hot environment. <\/jats:p>","DOI":"10.1152\/ajpregu.00355.2016","type":"journal-article","created":{"date-parts":[[2017,3,22]],"date-time":"2017-03-22T20:40:35Z","timestamp":1490215235000},"page":"R873-R882","source":"Crossref","is-referenced-by-count":13,"title":["Muscle sympathetic nerve activity response to heat stress is attenuated in chronic heart failure patients"],"prefix":"10.1152","volume":"312","author":[{"given":"Jian","family":"Cui","sequence":"first","affiliation":[{"name":"Penn State Heart and Vascular Institute, Penn State Hershey, Milton S. Hershey Medical Center, Hershey, Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Boehmer","sequence":"additional","affiliation":[{"name":"Penn State Heart and Vascular Institute, Penn State Hershey, Milton S. Hershey Medical Center, Hershey, Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheryl","family":"Blaha","sequence":"additional","affiliation":[{"name":"Penn State Heart and Vascular Institute, Penn State Hershey, Milton S. Hershey Medical Center, Hershey, Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lawrence I.","family":"Sinoway","sequence":"additional","affiliation":[{"name":"Penn State Heart and Vascular Institute, Penn State Hershey, Milton S. Hershey Medical Center, Hershey, Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.95.2.316"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1161\/hc4301.098282"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2008.03.056"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0b013e31817fbe11"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.100.3.280"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000146335.69413.F9"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198409273111303"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1999.277.6.H2348"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.105.540773"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2006.116640"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.112.000135"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.12492"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00195.2002"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1097\/00000441-196110000-00012"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-1716.1991.tb09148.x"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1007\/BF01826234"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(92)90998-E"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-201X.2003.01087.x"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1987.63.3.930"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1113\/JP270162"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.92.11.3206"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehi655"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.73.4.615"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1994.267.3.H994"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2006.108662"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.2001.280.6.H2868"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00202.2003"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.2001.0861h.x"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(01)01824-1"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00779.2010"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.73.5.913"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00498.2011"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1002\/clc.4960181303"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.77.4.721"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.15.5.505"},{"key":"B36","first-page":"174","volume-title":"Human Circulation Regulation During Physical Stress","author":"Rowell LB","year":"1986"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1970.28.4.415"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1971.31.6.864"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1016\/S0749-3797(99)00025-2"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199607113350203"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1985.58.2.400"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00228.2006"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.84.5.2034"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(02)01685-6"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1161\/hy1201.096120"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.91.10.2582"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1979.59.4.919"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-1716.2007.01730.x"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1975.38.1.58"},{"key":"B50","first-page":"25","volume-title":"Perspectives in Heart Failure Proceedings of the Congress Italian Society of Cardiology","author":"Zelis R","year":"1995"}],"container-title":["American Journal of Physiology-Regulatory, Integrative and Comparative Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/ajpregu.00355.2016","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,8]],"date-time":"2019-09-08T13:27:41Z","timestamp":1567949261000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/ajpregu.00355.2016"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6,1]]},"references-count":50,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2017,6,1]]}},"alternative-id":["10.1152\/ajpregu.00355.2016"],"URL":"https:\/\/doi.org\/10.1152\/ajpregu.00355.2016","relation":{},"ISSN":["0363-6119","1522-1490"],"issn-type":[{"value":"0363-6119","type":"print"},{"value":"1522-1490","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,6,1]]}}}