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In the present study, we tested the hypothesis that I\/R of the kidney reduces serum testosterone, and that contributes to renal dysfunction and injury. Male rats that were subjected to renal ischemia of 40 min followed by reperfusion had a 90% reduction in serum testosterone by 3 h after reperfusion that remained at 24 h. Acute infusion of testosterone 3 h after reperfusion attenuated the increase in plasma creatinine and urinary kidney injury molecule-1 (KIM-1) at 24 h, prevented the reduction in outer medullary blood flow, and attenuated the increase in intrarenal TNF-\u03b1 and the decrease in intrarenal VEGF at 48 h. Castration of males caused greater increases in plasma creatinine and KIM-1 at 24 h than in intact males with renal I\/R, and treatment with anastrozole, an aromatase inhibitor, plus testosterone almost normalized plasma creatinine and KIM-1 in rats with renal I\/R. These data show that renal I\/R is associated with sustained reductions in testosterone, that testosterone repletion protects the kidney, whereas castration promotes renal dysfunction and injury, and that the testosterone-mediated protection is not conferred by conversion to estradiol.<\/jats:p>","DOI":"10.1152\/ajpregu.00360.2012","type":"journal-article","created":{"date-parts":[[2013,4,4]],"date-time":"2013-04-04T06:37:48Z","timestamp":1365057468000},"page":"R951-R958","source":"Crossref","is-referenced-by-count":45,"title":["Protective role of testosterone in ischemia-reperfusion-induced acute kidney injury"],"prefix":"10.1152","volume":"304","author":[{"given":"Andrea","family":"Soljancic","sequence":"first","affiliation":[{"name":"Department of Medicine, Division of Nephrology, University of Mississippi Medical Center, Jackson, Mississippi; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arnaldo Lopez","family":"Ruiz","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Nephrology, University of Mississippi Medical Center, Jackson, Mississippi; 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