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They consumed 6.4\u2009g\/day of \u03b2-alanine or PL for 28\u2009days. Muscle biopsies of the active deltoid and the inactive vastus lateralis (VL) were taken before and after supplementation. MCarn in the VL was also compared with the VL of a group of individuals without paraplegia ( n = 15). MCarn was quantified in whole muscle and in pools of individual fibers by high-performance liquid chromatography. MCarn was higher in chronically inactive VL vs. well-trained deltoid (32.0\u2009\u00b1\u200912.0 vs. 20.5\u2009\u00b1\u20096.1\u2009mmol\/kg DM; P = 0.018). MCarn was higher in inactive vs. active VL (32.0\u2009\u00b1\u200912.0 vs. 21.2\u2009\u00b1\u20097.5\u2009mmol\/kg DM; P = 0.011). In type-I fibers, MCarn was significantly higher in the inactive VL than in the active deltoid (38.3\u2009\u00b1\u20094.7 vs. 27.3\u2009\u00b1\u200911.8\u2009mmol\/kg DM, P = 0.014). MCarn increased similarly between inactive VL and active deltoid in the \u03b2-alanine group (VL: 68.9\u2009\u00b1\u200955.1%, P = 0.0002; deltoid: 90.5\u2009\u00b1\u200951.4%, P &lt; 0.0001), with no changes in the PL group. MCarn content was higher in the inactive VL than in the active deltoid and the active VL, but this is probably a consequence of fiber type shift (type I to type II) that occurs with chronic inactivity. Chronically inactive muscle showed an increase in MCarn after BA supplementation equally to the active muscle, suggesting that carnosine accretion following \u03b2-alanine supplementation is not influenced by muscle inactivity. <\/jats:p>","DOI":"10.1152\/ajpregu.00360.2020","type":"journal-article","created":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T02:19:51Z","timestamp":1617243591000},"page":"R824-R832","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":7,"title":["The role of chronic muscle (in)activity on carnosine homeostasis: a study with spinal cord-injured athletes"],"prefix":"10.1152","volume":"320","author":[{"given":"Kleiner","family":"Nemezio","sequence":"first","affiliation":[{"name":"Applied Physiology and Nutrition Research Group, School of Physical Education and Sport, Faculdade de Medicina, Divis\u00e3o de Reumatologia, Universidade de S\u00e3o Paulo, S\u00e3o Paulo, 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