{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T13:38:40Z","timestamp":1758893920080,"version":"3.37.3"},"reference-count":35,"publisher":"American Physiological Society","issue":"5","funder":[{"DOI":"10.13039\/100000050","name":"HHS | NIH | National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01 HL106511","R01 HL130848","R01 HL102472","R01 HL119464"],"award-info":[{"award-number":["R01 HL106511","R01 HL130848","R01 HL102472","R01 HL119464"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"HHS | NIH | National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01 HL137368","R01 HL102472","R01 HL119464"],"award-info":[{"award-number":["R01 HL137368","R01 HL102472","R01 HL119464"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"HHS | NIH | National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01 HL137405"],"award-info":[{"award-number":["R01 HL137405"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"HHS | NIH | National Institute on Aging","doi-asserted-by":"publisher","award":["R21 AG053514"],"award-info":[{"award-number":["R21 AG053514"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000052","name":"HHS | NIH | NIH Office of the Director","doi-asserted-by":"publisher","award":["S10 OD025238"],"award-info":[{"award-number":["S10 OD025238"]}],"id":[{"id":"10.13039\/100000052","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Regulatory, Integrative and Comparative Physiology"],"published-print":{"date-parts":[[2020,5,1]]},"abstract":"<jats:p> The goal of this investigation was to compare the effects of chronic (4 wk) transverse aortic constriction (TAC) in Sprague-Dawley rats and C57BL\/6J mice. TAC, after 1 day, induced similar left ventricular (LV) pressure gradients in both rats ( n = 7) and mice ( n = 7) (113\u2009\u00b1\u20095.4 vs. 103\u2009\u00b1\u200911.5 mmHg), and after 4 wk, the percent increase in LV hypertrophy, as reflected by LV\/tibial length (51% vs 49%), was similar in rats ( n = 12) and mice ( n = 12). After 4 wk of TAC, LV systolic and diastolic function were preserved in TAC rats. In contrast, in TAC mice, LV ejection fraction decreased by 31% compared with sham, along with increases in LV end-diastolic pressure (153%) and LV systolic wall stress (86%). Angiogenesis, as reflected by Ki67 staining of capillaries, increased more in rats ( n = 6) than in mice ( n = 6; 10\u2009\u00b1\u20092 vs. 6\u2009\u00b1\u20091 Ki67-positive cells\/field). Myocardial blood flow fell by 55% and coronary reserve by 28% in mice with TAC ( n = 4), but they were preserved in rats ( n = 4). Myogenesis, as reflected by c-kit-positive myocytes staining positively for troponin I, is another mechanism that can confer protection after TAC. However, the c-kit-positive cells in rats with TAC were all negative for troponin I, indicating the absence of myogenesis. Thus, rats showed relative tolerance to severe pressure overload compared with mice, with mechanisms involving angiogenesis but not myogenesis. <\/jats:p>","DOI":"10.1152\/ajpregu.00370.2019","type":"journal-article","created":{"date-parts":[[2020,3,25]],"date-time":"2020-03-25T23:28:28Z","timestamp":1585178908000},"page":"R894-R900","source":"Crossref","is-referenced-by-count":6,"title":["Rats are protected from the stress of chronic pressure overload compared with mice"],"prefix":"10.1152","volume":"318","author":[{"given":"Koichi","family":"Nishimura","sequence":"first","affiliation":[{"name":"Department of Cell Biology and Molecular Medicine, Rutgers New Jersey Medical School, Newark, New Jersey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marko","family":"Oydanich","sequence":"additional","affiliation":[{"name":"Department of Cell Biology and Molecular Medicine, Rutgers New Jersey Medical School, Newark, New Jersey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Cell Biology and Molecular Medicine, Rutgers New Jersey Medical School, Newark, New Jersey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Denis","family":"Babici","sequence":"additional","affiliation":[{"name":"Department of Cell Biology and Molecular Medicine, Rutgers New Jersey Medical School, Newark, New Jersey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diego","family":"Fraidenraich","sequence":"additional","affiliation":[{"name":"Department of Cell Biology and Molecular Medicine, Rutgers New Jersey Medical School, Newark, New Jersey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dorothy E.","family":"Vatner","sequence":"additional","affiliation":[{"name":"Department of Cell Biology and Molecular Medicine, Rutgers New Jersey Medical School, Newark, New Jersey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0521-8634","authenticated-orcid":false,"given":"Stephen F.","family":"Vatner","sequence":"additional","affiliation":[{"name":"Department of Cell Biology and Molecular Medicine, Rutgers New Jersey Medical School, Newark, New Jersey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0510997103"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(98)00347-7"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2014-306151"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2005.062422"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00998.2010"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00148.2010"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.668681"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00532.2008"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.115.305373"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1007\/s10554-015-0827-3"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1016\/j.scr.2015.10.017"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.110.989665"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000020689.12472.E0"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2014.01.061"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1097\/FJC.0b013e31827fe59c"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.114.300507"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1733772100"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1038\/35070587"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1136\/openhrt-2019-001075"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1007\/s00395-012-0324-y"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1161\/hc0402.102931"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1172\/JCI24682"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvn001"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms9701"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1053\/j.jvca.2018.04.048"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(90)90620-5"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0600635103"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1832855100"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1038\/nature13309"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(93)90460-I"},{"key":"B31","first-page":"III8","volume":"81","author":"Vatner SF","year":"1990","journal-title":"Circulation"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.108.839068"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.115.305919"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.116.308139"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.111.173500"}],"container-title":["American Journal of Physiology-Regulatory, Integrative and Comparative Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/ajpregu.00370.2019","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,4,17]],"date-time":"2020-04-17T13:37:29Z","timestamp":1587130649000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/ajpregu.00370.2019"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5,1]]},"references-count":35,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2020,5,1]]}},"alternative-id":["10.1152\/ajpregu.00370.2019"],"URL":"https:\/\/doi.org\/10.1152\/ajpregu.00370.2019","relation":{},"ISSN":["0363-6119","1522-1490"],"issn-type":[{"type":"print","value":"0363-6119"},{"type":"electronic","value":"1522-1490"}],"subject":[],"published":{"date-parts":[[2020,5,1]]}}}