{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,17]],"date-time":"2025-12-17T23:00:29Z","timestamp":1766012429432,"version":"3.37.3"},"reference-count":32,"publisher":"American Physiological Society","issue":"5","funder":[{"name":"Regional Health Authority in Western Norway"},{"name":"\u00c5ke Wiberg foundation"},{"DOI":"10.13039\/501100003793","name":"Hj\u00e4rt-Lungfonden (Swedish Heart-Lung Foundation)","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003793","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003748","name":"Svenska S\u00e4llskapet f\u00f6r Medicinsk Forskning (Swedish Society for Medical Research)","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003748","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Marcus Borgstr\u00f6m foundation"},{"DOI":"10.13039\/501100007687","name":"Swedish Society of Medicine","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100007687","id-type":"DOI","asserted-by":"crossref"}]},{"name":"European Union FP7 CarTarDis consortium"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Regulatory, Integrative and Comparative Physiology"],"published-print":{"date-parts":[[2019,5,1]]},"abstract":"<jats:p>The genetic background of a mouse strain determines its susceptibility to disease. C57BL\/6J and Balb\/CJ are two widely used inbred mouse strains that we found react dramatically differently to angiotensin II and high-salt diet (ANG II + Salt). Balb\/CJ show increased mortality associated with anuria and edema formation while C57BL\/6J develop arterial hypertension but do not decompensate and die. Clinical symptoms of heart failure in Balb\/CJ mice gave the hypothesis that ANG II + Salt impairs cardiac function and induces cardiac remodeling in male Balb\/CJ but not in male C57BL\/6J mice. To test this hypothesis, we measured cardiac function using echocardiography before treatment and every day for 7 days during treatment with ANG II + Salt. Interestingly, pulsed wave Doppler of pulmonary artery flow indicated increased pulmonary vascular resistance and right ventricle systolic pressure in Balb\/CJ mice, already 24 h after ANG II + Salt treatment was started. In addition, Balb\/CJ mice showed abnormal diastolic filling indicated by reduced early and late filling and increased isovolumic relaxation time. Furthermore, Balb\/CJ exhibited lower cardiac output compared with C57BL\/6J even though they retained more sodium and water, as assessed using metabolic cages. Left posterior wall thickness increased during ANG II + Salt treatment but did not differ between the strains. In conclusion, ANG II + Salt treatment causes early restriction of pulmonary flow and reduced left ventricular filling and cardiac output in Balb\/CJ, which results in fluid retention and peripheral edema. This makes Balb\/CJ a potential model to study the adaptive capacity of the heart for identifying new disease mechanisms and drug targets.<\/jats:p>","DOI":"10.1152\/ajpregu.00373.2018","type":"journal-article","created":{"date-parts":[[2019,3,6]],"date-time":"2019-03-06T20:08:33Z","timestamp":1551902913000},"page":"R563-R570","source":"Crossref","is-referenced-by-count":5,"title":["Time course of decompensation after angiotensin II and high-salt diet in Balb\/CJ mice suggests pulmonary hypertension-induced cardiorenal syndrome"],"prefix":"10.1152","volume":"316","author":[{"given":"Mediha","family":"Becirovic-Agic","sequence":"first","affiliation":[{"name":"Integrative physiology, Department of Medical Cell Biology, Uppsala University, Uppsala, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1110-9488","authenticated-orcid":false,"given":"Sofia","family":"J\u00f6nsson","sequence":"additional","affiliation":[{"name":"Integrative physiology, Department of Medical Cell Biology, Uppsala University, Uppsala, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria K.","family":"Tveitar\u00e5s","sequence":"additional","affiliation":[{"name":"Department of Biomedicine, University of Bergen, Bergen, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Trude","family":"Skogstrand","sequence":"additional","affiliation":[{"name":"Department of Biomedicine, University of Bergen, Bergen, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tine V.","family":"Karlsen","sequence":"additional","affiliation":[{"name":"Department of Biomedicine, University of Bergen, Bergen, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00c5sa","family":"Lid\u00e9n","sequence":"additional","affiliation":[{"name":"Department of Biomedicine, University of Bergen, Bergen, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sabine","family":"Leh","sequence":"additional","affiliation":[{"name":"Department of Pathology, Haukeland University Hospital, Bergen, Norway"},{"name":"Department of Clinical Medicine, University of Bergen, Bergen, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Madelene","family":"Ericsson","sequence":"additional","affiliation":[{"name":"Department of Medical Biosciences, Ume\u00e5 University, Ume\u00e5, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan K.","family":"Nilsson","sequence":"additional","affiliation":[{"name":"Department of Medical Biosciences, Ume\u00e5 University, Ume\u00e5, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rolf K.","family":"Reed","sequence":"additional","affiliation":[{"name":"Department of Biomedicine, University of Bergen, Bergen, Norway"},{"name":"Centre for Cancer Biomarkers (CCBIO), University of Bergen, Bergen, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4675-1099","authenticated-orcid":false,"given":"Michael","family":"Hultstr\u00f6m","sequence":"additional","affiliation":[{"name":"Integrative physiology, Department of Medical Cell Biology, Uppsala University, Uppsala, Sweden"},{"name":"Department of Biomedicine, University of Bergen, Bergen, Norway"},{"name":"Anesthesia and intensive care, Department of Surgical Sciences, Uppsala University, Uppsala, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvn230"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.122.2.755"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/j.vph.2018.01.008"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.5339\/gcsp.2014.29"},{"key":"B5","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1042\/cs0960261","volume":"96","author":"Ferri C","year":"1999","journal-title":"Clin Sci (Lond)"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2006060677"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00595.2013"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2005.06.010"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.21805"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1111\/bph.13344"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1161\/RES.0b013e3182582523"},{"key":"B12","first-page":"284","volume":"122","author":"Huber SA","year":"1986","journal-title":"Am J Pathol"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2567.2009.03157.x"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00483.2018"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201110-1860OC"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2016.12.080"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1172\/JCI116909"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.35.4.985"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.320.7234.559"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2003.025270"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-0115(99)00004-X"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.01076.2005"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1042\/CS20120461"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1113\/expphysiol.2011.057612"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.4065\/mcp.2009.0494"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.113.300268"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199908193410806"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.01960408"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1016\/S0895-7061(02)02972-2"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1097\/EJA.0b013e328335474e"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCIMAGING.109.887109"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000033224.99806.8A"}],"container-title":["American Journal of Physiology-Regulatory, Integrative and Comparative Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/ajpregu.00373.2018","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,13]],"date-time":"2022-09-13T02:58:02Z","timestamp":1663037882000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/ajpregu.00373.2018"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5,1]]},"references-count":32,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2019,5,1]]}},"alternative-id":["10.1152\/ajpregu.00373.2018"],"URL":"https:\/\/doi.org\/10.1152\/ajpregu.00373.2018","relation":{},"ISSN":["0363-6119","1522-1490"],"issn-type":[{"type":"print","value":"0363-6119"},{"type":"electronic","value":"1522-1490"}],"subject":[],"published":{"date-parts":[[2019,5,1]]}}}