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Daily intake of 0.3 M NaCl increased to 46 \u00b1 15 and 130 \u00b1 6 ml\/24 h after 6 days of infusion of 10 and 100 ng\/h of aldosterone into the 4th V (intake with vehicle infusion: 2 \u00b1 1 ml\/24 h). Water intake fell slightly and not consistently, and food intake was not affected by aldosterone. Sodium appetite induced by diuretic (furosemide) combined with 24 h of a low-sodium diet fell from 12 \u00b1 1.7 ml\/2 h to 5.6 \u00b1 0.8 ml\/2 h after injection of the MR antagonist RU 28318 (100 ng\/2 \u03bcl) into the 4th V. RU 28318 also reduced the intake of 0.3 M NaCl induced by 9 days of a low-sodium diet from 9.5 \u00b1 2.6 ml\/2 h to 1.2 \u00b1 0.6 ml\/2 h. Infusion of 100 or 500 ng\/h of aldosterone into the LV did not affect daily intake of 0.3 M NaCl. 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