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The esophagus was cannulated and perfused with either 0.1 M PBS or 0.1 N HCl at 1 ml\/min as the following parameters were quantified in separate experiments: diameter of bronchi ( n = 5), tracheal mucociliary transport rate ( n = 4), tracheobronchial mucus secretion ( n = 7), and lung function ( n = 6). We found that esophageal acidification for 10\u201330 min decreased bronchial diameters primarily of the smaller low-resistance airways (10\u201322%, P &lt; 0.05), decreased tracheal mucociliary transport (53%, 8.7 \u00b1 2.4 vs. 4.1 \u00b1 1.3 mm\/min, P &lt; 0.05), increased tracheobronchial mucus secretion (147%, 3.4 \u00b1 0.7 vs. 8.4 \u00b1 2.6 mg\/10 min, P &lt; 0.05), and caused no change in total lung resistance or dynamic compliance ( P &gt; 0.05). Considering that tracheal mucociliary transport rate is governed in part by mucus secretion, we concluded that the primary airway response to esophageal acidification observed is increased mucus secretion. Airway constriction may act to assist in rapid secretion of mucus and to increase the effectiveness of coughing while not affecting lung resistance or compliance. Given the buffering capabilities of mucus, esophageal acidification activates appropriate physiological responses that may act to neutralize gastroesophageal reflux that reaches the larynx, pharynx, or lower airways. <\/jats:p>","DOI":"10.1152\/ajpregu.00394.2007","type":"journal-article","created":{"date-parts":[[2007,10,11]],"date-time":"2007-10-11T01:10:35Z","timestamp":1192065035000},"page":"R211-R219","source":"Crossref","is-referenced-by-count":25,"title":["Airway responses to esophageal acidification"],"prefix":"10.1152","volume":"294","author":[{"given":"Ivan M.","family":"Lang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven T.","family":"Haworth","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bidyut K.","family":"Medda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David L.","family":"Roerig","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hubert V.","family":"Forster","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reza","family":"Shaker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","reference":[{"key":"R1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.90.3.358"},{"key":"R2","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(96)13050-0"},{"key":"R3","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1971.31.5.651"},{"key":"R4","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1970.29.5.646"},{"key":"R5","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1991.71.5.2050"},{"key":"R6","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1982.52.4.984"},{"key":"R7","doi-asserted-by":"crossref","unstructured":"Daoui S, D'Agostino B, Gallelli L, Emonds X, Rossi F, Avenier C. 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