{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T07:31:45Z","timestamp":1791185505517,"version":"4.1.0"},"reference-count":30,"publisher":"American Physiological Society","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Regulatory, Integrative and Comparative Physiology"],"published-print":{"date-parts":[[2002,3,1]]},"abstract":"<jats:p> We tested the hypothesis that ovarian steroids stimulate breathing through a dopaminergic mechanism in the carotid bodies. In ovariectomized female rats raised at sea level, domperidone, a peripheral D<jats:sub>2<\/jats:sub>-receptor antagonist, increased ventilation in normoxia (minute ventilation = +55%) and acute hypoxia (+32%). This effect disappeared after 10 daily injections of ovarian steroids (progesterone + estradiol). At high altitude (3,600 m, Bolivian Institute for High-Altitude Biology-IBBA, La Paz, Bolivia), neutered females had higher carotid body tyrosine hydroxylase activity (the rate-limiting enzyme for catecholamine synthesis: +129%) and dopamine utilization (+150%), lower minute ventilation (\u221230%) and hypoxic ventilatory response (\u221257%), and higher hematocrit (+18%) and Hb concentration (+21%) than intact female rats. Consistent signs of arterial pulmonary hypertension (right ventricular hypertrophy) also appeared in ovariectomized females. None of these parameters was affected by gonadectomy in males. Our results show that ovarian steroids stimulate breathing by lowering a peripheral dopaminergic inhibitory drive. This process may partially explain the deacclimatization of postmenopausal women at high altitude. <\/jats:p>","DOI":"10.1152\/ajpregu.00398.2001","type":"journal-article","created":{"date-parts":[[2015,3,3]],"date-time":"2015-03-03T15:23:57Z","timestamp":1425396237000},"page":"R765-R773","source":"Crossref","is-referenced-by-count":66,"title":["Dopaminergic metabolism in carotid bodies and  high-altitude acclimatization in female rats"],"prefix":"10.1152","volume":"282","author":[{"given":"Vincent","family":"Joseph","sequence":"first","affiliation":[{"name":"Centre d'\u00c9tude des Rythmes Biologiques, Universit\u00e9 Libre de Bruxelles-H\u00f4pital Erasme, B-1070 Brussels, Belgium;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge","family":"Soliz","sequence":"additional","affiliation":[{"name":"Physiologisches Institut, Universit\u00e4t Z\u00fcrich-Irchel, CH-8057 Zurich, Switzerland;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruddy","family":"Soria","sequence":"additional","affiliation":[{"name":"Instituto Boliviano de Biolog\u0131\u0301a de Altura, Embajada de Francia, La Paz, Bolivia; 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