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Whether this applies also to the tail vasoconstrictor response in fever is unknown. Single- or a few-unit tail sympathetic nerve activity (SNA) was recorded in urethane-anesthetized, artificially ventilated rats. Experimental fever was induced by PGE<jats:sub>2<\/jats:sub>injected into the lateral cerebral ventricle (50 ng in 1.5 \u03bcl icv) or into the RMPO (0.2 ng in 60 nl); in both cases, there was a robust increase in tail SNA and a delayed rise in core temperature. Microinjection of glutamate receptor antagonist kynurenate (50 mM, 120 nl) into the medullary raph\u00e9 completely reversed the tail SNA response to intracerebroventricular or RMPO PGE<jats:sub>2<\/jats:sub>injection. Inhibiting RMPO neurons by microinjecting glycine (0.5 M, 60 nl) or the GABA<jats:sub>A<\/jats:sub>receptor agonist, muscimol (2 mM, 30\u201360 nl), reduced the tail SNA response to PGE<jats:sub>2<\/jats:sub>injected into the same site by approximately half. Vehicle injections into the medullary raph\u00e9 or RMPO were without effect. These results suggest that the tail vasoconstrictor response during experimental fever depends on a glutamatergic excitatory synaptic relay in the medullary raph\u00e9 and that an excitatory output signal from the RMPO contributes to the tail vasoconstrictor response during fever.<\/jats:p>","DOI":"10.1152\/ajpregu.00401.2013","type":"journal-article","created":{"date-parts":[[2013,10,17]],"date-time":"2013-10-17T04:20:33Z","timestamp":1381983633000},"page":"R1479-R1489","source":"Crossref","is-referenced-by-count":21,"title":["Role of an excitatory preoptic-raph\u00e9 pathway in febrile vasoconstriction of the rat's tail"],"prefix":"10.1152","volume":"305","author":[{"given":"Mutsumi","family":"Tanaka","sequence":"first","affiliation":[{"name":"Florey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, Victoria, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael 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