{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T21:48:47Z","timestamp":1788558527801,"version":"build-2803163510"},"reference-count":37,"publisher":"American Physiological Society","issue":"3","funder":[{"DOI":"10.13039\/100000062","name":"HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)","doi-asserted-by":"publisher","award":["DK-094905"],"award-info":[{"award-number":["DK-094905"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)","doi-asserted-by":"publisher","award":["DK-102427"],"award-info":[{"award-number":["DK-102427"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)","doi-asserted-by":"publisher","award":["DK-091253"],"award-info":[{"award-number":["DK-091253"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Regulatory, Integrative and Comparative Physiology"],"published-print":{"date-parts":[[2017,3,1]]},"abstract":"<jats:p> This study investigated the role of \u03b3-aminobutyric acid subtype B (GABA<jats:sub>B<\/jats:sub>) receptors in tibial and pudendal neuromodulation of bladder overactivity induced by intravesical administration of dilute (0.5%) acetic acid (AA) in \u03b1-chloralose-anesthetized cats. To inhibit bladder overactivity, tibial or pudendal nerve stimulation (TNS or PNS) was applied at 5 Hz and two or four times threshold (T) intensity for inducing toe or anal sphincter twitch. TNS at 2T or 4T intensity significantly ( P &lt; 0.05) increased the bladder capacity to 173.8 \u00b1 16.2 or 198.5 \u00b1 24.1%, respectively, of control capacity. Meanwhile, PNS at 2T or 4T intensity significantly ( P &lt; 0.05) increased the bladder capacity to 217 \u00b1 18.8 and 221.3 \u00b1 22.3% of control capacity, respectively. CGP52432 (a GABA<jats:sub>B<\/jats:sub> receptor antagonist) at intravenous dosages of 0.1\u20131 mg\/kg completely removed the TNS inhibition in female cats but had no effect in male cats. CGP52432 administered intravenously also had no effect on control bladder capacity or the pudendal inhibition of bladder overactivity. These results reveal a sex difference in the role of GABA<jats:sub>B<\/jats:sub> receptors in tibial neuromodulation of bladder overactivity in cats and that GABA<jats:sub>B<\/jats:sub> receptors are not involved in either pudendal neuromodulation or irritation-induced bladder overactivity. <\/jats:p>","DOI":"10.1152\/ajpregu.00401.2016","type":"journal-article","created":{"date-parts":[[2016,12,14]],"date-time":"2016-12-14T23:06:56Z","timestamp":1481756816000},"page":"R292-R300","source":"Crossref","is-referenced-by-count":14,"title":["Sex difference in the contribution of GABA<sub>B<\/sub> receptors to tibial neuromodulation of bladder overactivity in cats"],"prefix":"10.1152","volume":"312","author":[{"given":"Thomas W.","family":"Fuller","sequence":"first","affiliation":[{"name":"Department of Urology, University of Pittsburgh, Pittsburgh, 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