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P2 CD1 mouse pups with their dams were exposed to either CCH, where the Fi<jats:sub>O<jats:sub>2<\/jats:sub><\/jats:sub>was maintained at 11% continuously or to CIH, where the Fi<jats:sub>O<jats:sub>2<\/jats:sub><\/jats:sub>was varied between 21 and 11% every 4 min. P30 mice exposed to intermittent hypoxia for 4 wk demonstrated a significant decrease in the NAA\/Cr ratio in the hippocampus and thalamus, which was reversed by a subsequent exposure to 4 wk of normoxia. Meanwhile, mice exposed to 4 wk of constant hypoxia did not demonstrate any differences in their NAA\/Cr ratios from controls in these brain regions. These results indicate that an intermittent pattern of hypoxic exposure may have a more adverse effect on neuronal function and integrity than a continuous one. 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