{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T16:21:06Z","timestamp":1787242866270,"version":"build-2736575974"},"reference-count":50,"publisher":"American Physiological Society","issue":"4","funder":[{"name":"Autonomous Province of Vojvodina","award":["142-451- 2541"],"award-info":[{"award-number":["142-451- 2541"]}]},{"name":"EBM PhD Course, University of Split School of Medicine"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Regulatory, Integrative and Comparative Physiology"],"published-print":{"date-parts":[[2018,10,1]]},"abstract":"<jats:p>\n                    We examined if the diving-induced vascular changes in the peripheral and cerebral circulation could be prevented by oral antioxidant supplementation. Fourteen divers performed a single scuba dive to eighteen meter sea water for 47 min. Twelve of the divers participated in a follow-up study involving breathing 60% of oxygen at ambient pressure for 47 min. Before both studies, participants ingested vitamin C (2 g\/day) or a placebo capsule for 6 days. After a 2-wk washout, the study was repeated with the different condition. Endothelium-dependent vasodilator function of the brachial artery was assessed pre- and postintervention using the flow-mediated dilation (FMD) technique. Transcranial Doppler ultrasound was used to measure intracranial blood velocities pre- and 90 min postintervention. FMD was reduced by \u223c32.8% and \u223c21.2% postdive in the placebo and vitamin C trial and posthyperoxic condition in the placebo trial by \u223c28.2% ( P &lt; 0.05). This reduction in FMD was attenuated by \u223c10% following vitamin C supplementation in the hyperoxic study ( P &gt; 0.05). Elevations in intracranial blood velocities 30 min after surfacing from diving were reduced in the vitamin C study compared with the placebo trial ( P &lt; 0.05). O\n                    <jats:sub>2<\/jats:sub>\n                    breathing had no postintervention effects on intracranial velocities ( P &gt; 0.05). Prophylactic ingestion of vitamin C effectively abrogated peripheral vascular dysfunction following exposure to 60% O\n                    <jats:sub>2<\/jats:sub>\n                    but did not abolish the postdive decrease in FMD. Transient elevations of intracranial velocities postdive were reduced by vitamin C. These findings highlight the differential influence of vitamin C on peripheral and cerebral circulations following scuba diving, which are only partly mediated via hyperoxia.\n                  <\/jats:p>","DOI":"10.1152\/ajpregu.00412.2017","type":"journal-article","created":{"date-parts":[[2018,7,11]],"date-time":"2018-07-11T15:42:36Z","timestamp":1531323756000},"page":"R759-R767","source":"Crossref","is-referenced-by-count":9,"title":["Differential influence of vitamin C on the peripheral and cerebral circulation after diving and exposure to hyperoxia"],"prefix":"10.1152","volume":"315","author":[{"given":"Otto F.","family":"Barak","sequence":"first","affiliation":[{"name":"Department of Physiology, Faculty of Medicine, University of Novi Sad, Novi Sad, Serbia"},{"name":"Faculty of Sports and Physical Education, University of Novi Sad, Novi Sad, 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