{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T05:23:40Z","timestamp":1792301020339,"version":"4.4.0"},"reference-count":38,"publisher":"American Physiological Society","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Regulatory, Integrative and Comparative Physiology"],"published-print":{"date-parts":[[2008,1]]},"abstract":"<jats:p> Studies suggest that the inflammatory cytokine TNF-\u03b1 plays a role in the prognosis of end-stage renal diseases. We previously showed that TNF-\u03b1 inhibition slowed the progression of hypertension and renal damage in angiotensin II salt-sensitive hypertension. Thus, we hypothesize that TNF-\u03b1 contributes to renal inflammation in a model of mineralocorticoid-induced hypertension. Four groups of rats ( n = 5 or 6) were studied for 3 wk with the following treatments: 1) placebo, 2) placebo + TNF-\u03b1 inhibitor etanercept (1.25 mg\u00b7kg<jats:sup>\u22121<\/jats:sup>\u00b7day<jats:sup>\u22121<\/jats:sup> sc), 3) deoxycorticosterone acetate + 0.9% NaCl to drink (DOCA-salt), or 4) DOCA-salt + etanercept. Mean arterial blood pressure (MAP) measured by telemetry increased in DOCA-salt rats compared with baseline (177 \u00b1 4 vs. 107 \u00b1 3 mmHg; P &lt; 0.05), and TNF-\u03b1 inhibition had no effect in the elevation of MAP in these rats (177 \u00b1 8 mmHg). Urinary protein excretion significantly increased in DOCA-salt rats compared with placebo (703 \u00b1 76 vs. 198 \u00b1 5 mg\/day); etanercept lowered the proteinuria (514 \u00b1 64 mg\/day; P &lt; 0.05 vs. DOCA-salt alone). Urinary albumin excretion followed a similar pattern in each group. Urinary monocyte chemoattractant protein (MCP)-1 and endothelin (ET)-1 excretion were also increased in DOCA-salt rats compared with placebo (MCP-1: 939 \u00b1 104 vs. 43 \u00b1 7 ng\/day, ET-1: 3.30 \u00b1 0.29 vs. 1.07 \u00b1 0.03 fmol\/day; both P &lt; 0.05); TNF-\u03b1 inhibition significantly decreased both MCP-1 and ET-1 excretion (409 \u00b1 138 ng\/day and 2.42 \u00b1 0.22 fmol\/day, respectively; both P &lt; 0.05 vs. DOCA-salt alone). Renal cortical NF-\u03baB activity also increased in DOCA-salt hypertensive rats, and etanercept treatment significantly reduced this effect. These data support the hypothesis that TNF-\u03b1 contributes to the increase in renal inflammation in DOCA-salt rats. <\/jats:p>","DOI":"10.1152\/ajpregu.00466.2007","type":"journal-article","created":{"date-parts":[[2007,11,7]],"date-time":"2007-11-07T20:47:46Z","timestamp":1194468466000},"page":"R76-R83","source":"Crossref","is-referenced-by-count":126,"title":["TNF-\u03b1 inhibition reduces renal injury in DOCA-salt hypertensive rats"],"prefix":"10.1152","volume":"294","author":[{"given":"Ahmed A.","family":"Elmarakby","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey E.","family":"Quigley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John D.","family":"Imig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer S.","family":"Pollock","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David M.","family":"Pollock","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"R1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.1998.275.1.R245"},{"key":"R2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.14.1.649"},{"key":"R3","unstructured":"Bertani T, Abbate M, Zoja C, Corna D, Perico N, Ghezzi P, Remuzzi G. 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