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To determine the region where 5-HT<jats:sub>1A<\/jats:sub>receptor agonists act to mediate this response, recovery of mean arterial pressure (MAP), heart rate (HR), and renal sympathetic nerve activity (RSNA) was compared in hemorrhaged rats after injection of the selective 5-HT<jats:sub>1A<\/jats:sub>agonist, (+)-8-hydroxy-2-(di- n-propylamino)tetralin (8-OH-DPAT), in various regions of the cerebroventricular system or the systemic circulation. Three minutes after injection of 8-OH-DPAT (48 nmol\/kg), MAP and RSNA were higher in hemorrhaged rats given drug in the fourth ventricle (94 \u00b1 5 mmHg, 82 \u00b1 18% of baseline) or the systemic circulation (90 \u00b1 4 mmHg, 113 \u00b1 15% of baseline) than in rats given drug in the Aqueduct of Sylvius (63 \u00b1 4 mmHg, 27 \u00b1 11% of baseline), the lateral ventricle (42 \u00b1 3 mmHg, \u22128 \u00b1 18% of baseline), or in rats given saline in various brain regions (47 \u00b1 5 mmHg, \u221242 \u00b1 10% of baseline). A lower-dose injection of 8-OH-DPAT (10 nmol\/kg) also accelerated the recovery of MAP and RSNA in hemorrhaged rats when given in the fourth ventricle (94 \u00b1 26 mmHg, 72 \u00b1 33% of baseline 3 min after injection) but not the systemic circulation (46 \u00b1 4 mmHg, \u221225 \u00b1 30% of baseline). These data indicate that 8-OH-DPAT acts on receptors in the hindbrain to reverse the sympatholytic response to hemorrhage in conscious rats.<\/jats:p>","DOI":"10.1152\/ajpregu.00478.2002","type":"journal-article","created":{"date-parts":[[2015,3,3]],"date-time":"2015-03-03T20:27:41Z","timestamp":1425414461000},"page":"R782-R791","source":"Crossref","is-referenced-by-count":19,"title":["5-HT<sub>1A<\/sub>receptor agonist 8-OH-DPAT acts in the hindbrain to reverse the sympatholytic response to severe hemorrhage"],"prefix":"10.1152","volume":"284","author":[{"given":"Karie E.","family":"Scrogin","sequence":"first","affiliation":[{"name":"Department of Pharmacology and Experimental Therapeutics, Loyola University Chicago, Stritch School of Medicine, Maywood, Illinois 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