{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,5]],"date-time":"2025-10-05T16:55:32Z","timestamp":1759683332189},"reference-count":36,"publisher":"American Physiological Society","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Regulatory, Integrative and Comparative Physiology"],"published-print":{"date-parts":[[2002,7,1]]},"abstract":"<jats:p> It has been suggested that an opioidergic feeding pathway exists between the nucleus of the solitary tract (NTS) and the central nucleus of the amygdala. We studied the following three groups of rats: 1) artificial cerebrospinal fluid (CSF) infused in the NTS, 2) naltrexone (100 \u03bcg\/day) infused for 13 days in the NTS, and 3) artificial CSF infused in the NTS of rats pair fed to the naltrexone-infused group. Naltrexone administration resulted in a decrease in body weight and food intake. Also, naltrexone infusion increased dynorphin, but not enkephalin, gene expression in the amygdala, independent of the naltrexone-induced reduction in food intake. Gene expression of neuropeptide Y in the arcuate nucleus and neuropeptide Y peptide levels in the paraventricular nucleus did not change because of naltrexone infusion. However, naltrexone induced an increase in serum leptin compared with pair-fed controls. Thus chronic administration of naltrexone in the NTS increased dynorphin gene expression in the amygdala, further supporting an opioidergic feeding pathway between these two brain sites. <\/jats:p>","DOI":"10.1152\/ajpregu.00480.2001","type":"journal-article","created":{"date-parts":[[2015,3,3]],"date-time":"2015-03-03T20:24:31Z","timestamp":1425414271000},"page":"R161-R167","source":"Crossref","is-referenced-by-count":18,"title":["Opioid receptor blockade in rat nucleus tractus  solitarius alters amygdala dynorphin gene expression"],"prefix":"10.1152","volume":"283","author":[{"given":"Michael J.","family":"Glass","sequence":"first","affiliation":[{"name":"Weill Medical College, Cornell University, New York, New York 10021;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacquie E.","family":"Briggs","sequence":"additional","affiliation":[{"name":"Medicine, University of Minnesota, St. Paul, Minnesota 55108"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles J.","family":"Billington","sequence":"additional","affiliation":[{"name":"Minnesota Obesity Center,"},{"name":"Veterans Affairs Medical Center, Minneapolis 55417; 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