{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T14:02:42Z","timestamp":1791295362761,"version":"4.1.0"},"reference-count":65,"publisher":"American Physiological Society","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Regulatory, Integrative and Comparative Physiology"],"published-print":{"date-parts":[[2014,3,1]]},"abstract":"<jats:p> Exaggerated GLP-1 and PYY secretion is thought to be a major mechanism in the reduced food intake and body weight after Roux-en-Y gastric bypass surgery. Here, we use complementary pharmacological and genetic loss-of-function approaches to test the role of increased signaling by these gut hormones in high-fat diet-induced obese rodents. Chronic brain infusion of a supramaximal dose of the selective GLP-1 receptor antagonist exendin-9\u201339 into the lateral cerebral ventricle significantly increased food intake and body weight in both RYGB and sham-operated rats, suggesting that, while contributing to the physiological control of food intake and body weight, central GLP-1 receptor signaling tone is not the critical mechanism uniquely responsible for the body weight-lowering effects of RYGB. Central infusion of the selective Y2R-antagonist BIIE0246 had no effect in either group, suggesting that it is not critical for the effects of RYGB on body weight under the conditions tested. In a recently established mouse model of RYGB that closely mimics surgery and weight loss dynamics in humans, obese GLP-1R-deficient mice lost the same amount of body weight and fat mass and maintained similarly lower body weight compared with wild-type mice. Together, the results surprisingly provide no support for important individual roles of either gut hormone in the specific mechanisms by which RYGB rats settle at a lower body weight. It is likely that the beneficial effects of bariatric surgeries are expressed through complex mechanisms that require combination approaches for their identification. <\/jats:p>","DOI":"10.1152\/ajpregu.00491.2013","type":"journal-article","created":{"date-parts":[[2014,1,15]],"date-time":"2014-01-15T22:46:38Z","timestamp":1389825998000},"page":"R352-R362","source":"Crossref","is-referenced-by-count":160,"title":["GLP-1 receptor signaling is not required for reduced body weight after RYGB in rodents"],"prefix":"10.1152","volume":"306","author":[{"given":"Jianping","family":"Ye","sequence":"first","affiliation":[{"name":"Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, Louisiana;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng","family":"Hao","sequence":"additional","affiliation":[{"name":"Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, Louisiana;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael B.","family":"Mumphrey","sequence":"additional","affiliation":[{"name":"Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, Louisiana;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. 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