{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T21:46:39Z","timestamp":1792446399762,"version":"4.5.0"},"reference-count":68,"publisher":"American Physiological Society","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Regulatory, Integrative and Comparative Physiology"],"published-print":{"date-parts":[[2016,7,1]]},"abstract":"<jats:p> Cardiovagal baroreflex sensitivity (cvBRS) measures the efficiency of the cardiovagal baroreflex to modulate heart rate in response to increases or decreases in systolic blood pressure (SBP). Given that baroreceptors are located in the walls of the carotid sinuses (CS) and aortic arch (AA), the arterial mechanics of these sites are important contributors to cvBRS. However, the relative contribution of CS and AA mechanics to cvBRS remains unclear. This study employed sex differences as a model to test the hypothesis that differences in cvBRS between groups would be explained by the vascular mechanics of the AA but not the CS. Thirty-six young, healthy, normotensive individuals (18 females; 24 \u00b1 2 yr) were recruited. cvBRS was measured using transfer function analysis of the low-frequency region (0.04\u20130.15 Hz). Ultrasonography was performed at the CS and AA to obtain arterial diameters for the measurement of distensibility. Local pulse pressure (PP) was taken at the CS using a hand-held tonometer, whereas AA PP was estimated using a transfer function of brachial PP. Both cvBRS (25 \u00b1 11 vs. 19 \u00b1 7 ms\/mmHg, P = 0.04) and AA distensibility (16.5 \u00b1 6.0 vs. 10.5 \u00b1 3.8 mmHg<jats:sup>\u22121<\/jats:sup> \u00d7 10<jats:sup>\u22123<\/jats:sup>, P = 0.02) were greater in females than males. Sex differences in cvBRS were eliminated after controlling for AA distensibility ( P = 0.19). There were no sex differences in CS distensibility (5.32 \u00b1 2.3 vs. 4.63 \u00b1 1.3 mmHg<jats:sup>\u22121<\/jats:sup> \u00d7 10<jats:sup>\u22123<\/jats:sup>, P = 0.32). The present data demonstrate that AA mechanics are an important contributor to differences in cvBRS. <\/jats:p>","DOI":"10.1152\/ajpregu.00491.2015","type":"journal-article","created":{"date-parts":[[2016,4,28]],"date-time":"2016-04-28T12:41:58Z","timestamp":1461847318000},"page":"R24-R32","source":"Crossref","is-referenced-by-count":19,"title":["Role of aortic arch vascular mechanics in cardiovagal baroreflex sensitivity"],"prefix":"10.1152","volume":"311","author":[{"given":"Stephen A.","family":"Klassen","sequence":"first","affiliation":[{"name":"Faculty of Applied Health Sciences, Brock University, St. Catharines, Ontario, Canada;"},{"name":"Brock-Niagara Centre for Health and Well-Being, Brock University, St. Catharines, Ontario, Canada; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniele","family":"Chirico","sequence":"additional","affiliation":[{"name":"Faculty of Applied Health Sciences, Brock University, St. Catharines, Ontario, Canada;"},{"name":"Brock-Niagara Centre for Health and Well-Being, Brock University, St. Catharines, Ontario, Canada; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kylie S.","family":"Dempster","sequence":"additional","affiliation":[{"name":"Faculty of Applied Health Sciences, Brock University, St. Catharines, Ontario, Canada;"},{"name":"Brock-Niagara Centre for Health and Well-Being, Brock University, St. Catharines, Ontario, Canada; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. 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