{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T17:11:10Z","timestamp":1774458670821,"version":"3.50.1"},"reference-count":38,"publisher":"American Physiological Society","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Regulatory, Integrative and Comparative Physiology"],"published-print":{"date-parts":[[2004,4]]},"abstract":"<jats:p> In the present investigation we sought to determine if a perinatal high-salt treatment affects blood pressure at an early age (30 days), and if so, to determine the mechanisms responsible for the hypertension. Pregnant dams were given an 8% NaCl diet [high-salt (HS) rats] during the final one-third of gestation and throughout the suckling period. After weaning, the pups continued to receive the high-salt diet until testing at age 30 days. Control groups received a normal-salt diet (NS rats). In HS rats, mean arterial pressure (MAP) was significantly increased (110 \u00b1 5 vs. 96 \u00b1 3 mmHg) compared with NS rats. Blockade of brain AT<jats:sub>1<\/jats:sub> receptors with intracerebroventricular losartan decreased MAP in HS but not NS rats. Blockade of \u03b1-adrenergic receptors with intravenous phentolamine or ganglionic transmission with intravenous chlorisondamine produced a greater decrease in MAP in HS rats. Baroreflex control of heart rate was assessed using a four-parameter logistics function. The mid-range MAP (p3) was significantly increased in the HS rats. No other baroreflex parameters were affected. Specific binding of <jats:sup>125<\/jats:sup>I-[Sar<jats:sup>1<\/jats:sup>,Ile<jats:sup>8<\/jats:sup>]ANG II to AT<jats:sub>1<\/jats:sub> receptors was increased in the subfornical organ (SFO) of the HS rats. Expression of AT<jats:sub>1a<\/jats:sub> receptor mRNA was greater in both SFO and PVN of the HS rats. These data suggest that even at an early age, Sprague-Dawley rats treated with a perinatal high-salt diet are hypertensive. The elevated blood pressure appears to be caused by increased sympathetic nervous activity, resulting, in part, from increased brain AT<jats:sub>1<\/jats:sub> receptor activation. <\/jats:p>","DOI":"10.1152\/ajpregu.00492.2003","type":"journal-article","created":{"date-parts":[[2004,3,5]],"date-time":"2004-03-05T16:03:06Z","timestamp":1078502586000},"page":"R764-R770","source":"Crossref","is-referenced-by-count":15,"title":["Effect of a perinatal high-salt diet on blood pressure control mechanisms in young Sprague-Dawley rats"],"prefix":"10.1152","volume":"286","author":[{"given":"Steven J.","family":"Swenson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert C.","family":"Speth","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James P.","family":"Porter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","reference":[{"key":"REF1","doi-asserted-by":"publisher","DOI":"10.1016\/0031-9384(86)90247-7"},{"key":"REF2","doi-asserted-by":"publisher","DOI":"10.1096\/fj.01-0531fje"},{"key":"REF3","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.1989.256.1.R70"},{"key":"REF4","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-9384(00)00331-0"},{"key":"REF5","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1985.249.2.H278"},{"key":"REF6","unstructured":"Hall CE, Ayachi S, and Hall O. 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