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By immunohistochemical and in situ hybridization studies, we observed FGF-BP protein and mRNA upregulation in regenerating renal tubular epithelial cells from kidneys of HIV-Tg<jats:sub>26<\/jats:sub>mice with late-stage renal disease, that is, associated with the development of microcystic tubular dilatation and accumulation of FGF-2. Moreover, FGF-BP increased the FGF-2-dependent growth and survival of cultured primary human renal glomerular endothelial cells and enhanced FGF-2-induced MAPK\/ERK2 activation, as well as the proliferation of immortalized GM7373 endothelial cells. We propose that HIV-Tg<jats:sub>26<\/jats:sub>mice are a clinically relevant model system to study the role of FGF-BP in the pathogenesis of HIV-associated renal diseases. Furthermore, the upregulation of FGF-BP by regenerating renal tubular epithelial cells may provide a mechanism by which the regenerative and angiogenic activity of FGF-2 in renal capillaries can be modulated in children with HIV-HUS and other renal disease.<\/jats:p>","DOI":"10.1152\/ajpregu.00492.2005","type":"journal-article","created":{"date-parts":[[2005,12,13]],"date-time":"2005-12-13T23:27:42Z","timestamp":1134516462000},"page":"R105-R113","source":"Crossref","is-referenced-by-count":33,"title":["Role of fibroblast growth factor-binding protein in the pathogenesis of HIV-associated hemolytic uremic syndrome"],"prefix":"10.1152","volume":"290","author":[{"given":"Patricio E.","family":"Ray","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Tassi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue-Hui","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anton","family":"Wellstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"R1","doi-asserted-by":"publisher","DOI":"10.3109\/08977199509028957"},{"key":"R2","doi-asserted-by":"publisher","DOI":"10.1021\/bi00430a047"},{"key":"R3","doi-asserted-by":"publisher","DOI":"10.1042\/bj20021760"},{"key":"R4","doi-asserted-by":"publisher","DOI":"10.1042\/bj3030583"},{"key":"R5","doi-asserted-by":"publisher","DOI":"10.1126\/science.1957172"},{"key":"R6","doi-asserted-by":"publisher","DOI":"10.1038\/nm1097-1137"},{"key":"R7","doi-asserted-by":"crossref","unstructured":"Czubayko F, Riegel AT, and Wellstein A.Ribozyme-targeting elucidates a direct role of pleiotrophin in tumor growth.J Biol Chem269: 21,358\u201321,363, 1994.","DOI":"10.1016\/S0021-9258(17)31970-1"},{"key":"R8","doi-asserted-by":"crossref","unstructured":"Czubayko F, Smith RV, Chung HC, and Wellstein A.Tumor growth and angiogenesis induced by a secreted binding protein for fibroblast growth factors.J Biol Chem269: 28243\u201328248, 1994.","DOI":"10.1016\/S0021-9258(18)46920-7"},{"key":"R9","doi-asserted-by":"publisher","DOI":"10.1006\/excr.1996.0385"},{"key":"R10","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M005949200"},{"key":"R11","doi-asserted-by":"publisher","DOI":"10.1016\/0042-6822(91)90759-5"},{"key":"R12","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-291X(05)80280-3"},{"key":"R13","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.1041400110"},{"key":"R14","doi-asserted-by":"publisher","DOI":"10.1172\/JCI116126"},{"key":"R15","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtbi.2004.10.020"},{"key":"R16","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.1041300113"},{"key":"R17","unstructured":"Gasser C, Gautier E, Steck A, Siebenmann RE, and Oechslin R.[Scientific raisins from 127 years SMW (Swiss Medical Weekly). 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