{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T05:01:59Z","timestamp":1780722119029,"version":"3.54.1"},"reference-count":33,"publisher":"American Physiological Society","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Regulatory, Integrative and Comparative Physiology"],"published-print":{"date-parts":[[2013,6,15]]},"abstract":"<jats:p> The kidneys maintain extracellular K<jats:sup>+<\/jats:sup> homeostasis by altering K<jats:sup>+<\/jats:sup> excretion to match K<jats:sup>+<\/jats:sup> intake. Because this can occur without changes in plasma K<jats:sup>+<\/jats:sup> concentrations ([K<jats:sup>+<\/jats:sup>]), how the kidneys sense K<jats:sup>+<\/jats:sup> intake is unclear. We tested the hypothesis that the pituitary plays a critical role in signaling K<jats:sup>+<\/jats:sup> intake to the kidneys. If this hypothesis is true, hypophysectomy would impair kidney responses to altered K<jats:sup>+<\/jats:sup> intake. Hypophysectomized (Hypox) and sham-operated control rats ( n = 8 each) were compared for their abilities to adjust K<jats:sup>+<\/jats:sup> excretion during a transition from normal to reduced (to one-third of normal) K<jats:sup>+<\/jats:sup> intake, followed by a reversal to normal K<jats:sup>+<\/jats:sup> intake. Food was provided only at night, and renal K<jats:sup>+<\/jats:sup> excretion was determined both for absorptive (night or feeding) and postabsorptive (day or nonfeeding) periods. In normal rats, both absorptive and postabsorptive renal K<jats:sup>+<\/jats:sup> excretion were changed in parallel to the changes in K<jats:sup>+<\/jats:sup> intake, indicating a rapid adaptation of normal kidneys to altered K<jats:sup>+<\/jats:sup> intake. In Hypox rats, whereas absorptive renal K<jats:sup>+<\/jats:sup> excretion was changed in response to changes in K<jats:sup>+<\/jats:sup> intake, postabsorptive K<jats:sup>+<\/jats:sup> excretion was not responsive ( P &lt; 0.001), indicating impaired renal responses to altered K<jats:sup>+<\/jats:sup> intake. In addition, Hypox rats, compared with control rats, showed K<jats:sup>+<\/jats:sup> intolerance (increases in plasma [K<jats:sup>+<\/jats:sup>]) upon feeding (i.e., K<jats:sup>+<\/jats:sup> intake) at night or following an intravenous K<jats:sup>+<\/jats:sup> infusion ( P &lt; 0.01), indicating an impairment of acute renal responses to K<jats:sup>+<\/jats:sup> intake. These data support that the pituitary plays a key role in the signaling of K<jats:sup>+<\/jats:sup> intake to the kidneys (and kidney responses to altered K<jats:sup>+<\/jats:sup> intake). <\/jats:p>","DOI":"10.1152\/ajpregu.00495.2012","type":"journal-article","created":{"date-parts":[[2013,4,18]],"date-time":"2013-04-18T02:51:47Z","timestamp":1366253507000},"page":"R1166-R1174","source":"Crossref","is-referenced-by-count":18,"title":["Role of pituitary in K<sup>+<\/sup> homeostasis: impaired renal responses to altered K<sup>+<\/sup> intake in hypophysectomized rats"],"prefix":"10.1152","volume":"304","author":[{"given":"Young Taek","family":"Oh","sequence":"first","affiliation":[{"name":"Department of Physiology and Biophysics, University of Southern California, Keck School of Medicine, Los Angeles, California; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinyub","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Physiology and Biophysics, University of Southern California, Keck School of Medicine, Los Angeles, California; 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