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Before obstruction, one-third of the animals were premedicated for 7 days with l-NAME and another third with l-arginine. The results are summarized as follows. First, bladder weight after 8-wk PBOO was significantly lower in animals treated with l-arginine compared with both untreated and rabbits treated with l-NAME. Second, contractile function decreased progressively with PBOO duration. However, after 8 wk of PBOO, the l-arginine group had significantly greater contractile function compared with the no-treatment group, and the l-NAME group had significantly lower contractile function compared with the no-treatment group. Third, at 8 wk following PBOO, the level of protein oxidation and nitration was lowest for the l-arginine group and highest in the l-NAME group. These studies clearly demonstrated that increasing blood flow by stimulating NOS significantly protected the bladder from PBOO dysfunctions, whereas inhibiting blood flow by l-NAME enhanced the dysfunctions mediated by PBOO.<\/jats:p>","DOI":"10.1152\/ajpregu.00508.2007","type":"journal-article","created":{"date-parts":[[2007,10,11]],"date-time":"2007-10-11T01:10:35Z","timestamp":1192065035000},"page":"R2390-R2399","source":"Crossref","is-referenced-by-count":20,"title":["Effects of<scp>l<\/scp>-arginine and<scp>l<\/scp>-NAME on chronic partial bladder outlet obstruction in rabbit"],"prefix":"10.1152","volume":"293","author":[{"given":"Wei-Yu","family":"Lin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert 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