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In rats, we assessed whether placental ischemia results in long-term effects on the maternal cardiovascular and renal systems using the reduced uterine perfusion pressure (RUPP) model for PE. Sprague-Dawley rats received either a Sham or RUPP operation at gestational day 14. The rats were followed for 8 wk after delivery (Sham n = 12, RUPP n = 21) at which time mean arterial pressure (MAP; conscious), 24-h albuminuria, glomerular filtration rate (GFR; transcutaneous, FITC-sinistrin), and cardiac function (Vevo 770 system) were assessed. Subsequently, all rats were euthanized for mesenteric artery vasorelaxation and histology of heart and kidney. At 8 wk after delivery, there was no difference in MAP and albuminuria. However, RUPP rats showed a significantly reduced GFR [2.61\u2009\u00b1\u20090.53 vs. 3.37\u2009\u00b1\u20090.74 ml\/min; P = 0.01]. Ultrasound showed comparable cardiac structure, but RUPP rats had a lower left ventricular ejection fraction (62\u2009\u00b1\u20097 vs. 69\u2009\u00b1\u200910%; P = 0.04). Heart and kidney histology was not different between Sham or RUPP rats. Furthermore, there were no differences in endothelial-dependent or -independent vasorelaxation. We show that exposure to placental ischemia in rats is accompanied by functional disturbances in maternal renal and cardiac function 8 wk after a preeclamptic pregnancy. However, these changes were not dependent on differences in blood pressure, small artery vasorelaxation, or cardiac and renal structure at this time point postpartum. <\/jats:p>","DOI":"10.1152\/ajpregu.00510.2016","type":"journal-article","created":{"date-parts":[[2017,2,15]],"date-time":"2017-02-15T21:00:34Z","timestamp":1487192434000},"page":"R664-R670","source":"Crossref","is-referenced-by-count":35,"title":["Exposure to placental ischemia impairs postpartum maternal renal and cardiac function in rats"],"prefix":"10.1152","volume":"312","author":[{"given":"Nina D.","family":"Paauw","sequence":"first","affiliation":[{"name":"Department of Obstetrics, Wilhelmina Children\u2019s Hospital Birth Center, University Medical Center Utrecht, Utrecht, The Netherlands;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaap A.","family":"Joles","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Hypertension, University Medical Center Utrecht, Utrecht, The Netherlands;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank T.","family":"Spradley","sequence":"additional","affiliation":[{"name":"Department of Physiology, University of Mississippi Medical Center, Jackson, Mississippi; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bhavisha","family":"Bakrania","sequence":"additional","affiliation":[{"name":"Department of Physiology, University of Mississippi Medical Center, Jackson, Mississippi; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zsuzsanna K.","family":"Zsengeller","sequence":"additional","affiliation":[{"name":"Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arie","family":"Franx","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Wilhelmina Children\u2019s Hospital Birth Center, University Medical Center Utrecht, Utrecht, The Netherlands;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marianne C.","family":"Verhaar","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Hypertension, University Medical Center Utrecht, Utrecht, The Netherlands;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joey P.","family":"Granger","sequence":"additional","affiliation":[{"name":"Department of Physiology, University of Mississippi Medical Center, Jackson, Mississippi; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. 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