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In hypertensive rats, the increased systolic blood pressure was accompanied by an enhancement of serum aldosterone levels compared with WKY rats, but no alterations were found in their body weight or serum glucose\/insulin levels. The values for d-glucose maximal rate of transport (V<jats:sub>max<\/jats:sub>) were 42 and 60% lower, respectively, in the jejunum and ileum of SHR than those from WKY rats. On the other hand, the values for the Michaelis constant (K<jats:sub>m<\/jats:sub>) were similar in both animal groups, as was the diffusive component of transport (K<jats:sub>d<\/jats:sub>). Immunoblotting and Northern blot analysis revealed the existence of a lower abundance of SGLT1 protein and mRNA in SHR. Moreover, hypertensive rats showed a decrease in the molecular mass of SGLT1 that could not be explained in terms of different glycosylation and\/or phosphorylation levels or an alternative splicing in the expression of the protein. 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