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Results showed differential activation of ERK1\/2 and ERK5 in these regions following cystitis. The level of phospho-ERK1\/2 but not phospho-ERK5 was increased in the urinary bladder; the level of phospho-ERK5 but not phospho-ERK1\/2 was increased in DRG; and the level of phospho-ERK1\/2 but not phospho-ERK5 was increased in lumbar spinal cord following cystitis compared with control. Cystitis-induced upregulation of phospho-ERK1\/2 and phospho-ERK5 was time dependent and showed similar patterns in female and male rats. The level of phospho-ERK1\/2 in bladder was increased at 2 and 8 h after CYP injection; the level of phospho-ERK5 in DRG was increased at 8 and 48 h after CYP injection; and the level of phospho-ERK1\/2 in lumbar spinal cord was increased at 48 h after CYP injection. The result that phospho-ERK5 was exclusively increased in DRG neurons, while phospho-ERK1\/2 was increased in the spinal cord and the urinary bladder after cystitis, suggests a region-specific effect of neurotrophins on micturition pathways following bladder inflammation. <\/jats:p>","DOI":"10.1152\/ajpregu.00570.2006","type":"journal-article","created":{"date-parts":[[2006,11,17]],"date-time":"2006-11-17T01:59:13Z","timestamp":1163728753000},"page":"R1368-R1375","source":"Crossref","is-referenced-by-count":31,"title":["Region-specific changes in the phosphorylation of ERK1\/2 and ERK5 in rat micturition pathways following cyclophosphamide-induced cystitis"],"prefix":"10.1152","volume":"292","author":[{"given":"Li-Ya","family":"Qiao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melisa A.","family":"Gulick","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","reference":[{"key":"R1","doi-asserted-by":"publisher","DOI":"10.1006\/mcne.2001.1015"},{"key":"R2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(05)67495-2"},{"key":"R3","doi-asserted-by":"publisher","DOI":"10.1002\/neu.10322"},{"key":"R4","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2005.03893.x"},{"key":"R5","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2006.01.016"},{"key":"R6","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.22-17-07737.2002"},{"key":"R7","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(96)00575-1"},{"key":"R8","doi-asserted-by":"publisher","DOI":"10.1097\/01.brs.0000182091.53834.08"},{"key":"R9","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2005.07.055"},{"key":"R10","doi-asserted-by":"publisher","DOI":"10.1016\/0166-2236(92)90019-5"},{"key":"R11","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4899-1585-6_6"},{"key":"R12","doi-asserted-by":"publisher","DOI":"10.1016\/S0169-328X(03)00284-5"},{"key":"R13","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2006.03.010"},{"key":"R14","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00465.2002"},{"key":"R15","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)80602-9"},{"key":"R16","unstructured":"Ji RR. 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