{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,4,19]],"date-time":"2024-04-19T06:40:15Z","timestamp":1713508815292},"reference-count":47,"publisher":"American Physiological Society","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Regulatory, Integrative and Comparative Physiology"],"published-print":{"date-parts":[[2012,4,1]]},"abstract":"<jats:p>We have previously shown that fetal uninephrectomy (uni-x) at 100 days of gestation (term = 150 days) in male sheep results in a 30% nephron deficit, reduction in glomerular filtration rate (GFR) and renal blood flow, and elevation in arterial pressure at 6 mo of age. Furthermore, in response to an acute 0.9% saline load, sodium excretion was significantly delayed in uni-x animals leading us to speculate that tubuloglomerular feedback (TGF) activity was reset in uni-x animals. In the present study, we induced TGF blockade by furosemide administration (1.5 mg\/kg iv over 90 min) and determined GFR, effective renal plasma flow, and urine and sodium excretion responses in 6-mo-old male sheep. In response to furosemide, a significant diuresis and natriuresis was observed in the sham group; however, the response was significantly delayed and reduced in uni-x animals (both, P<jats:sub>treatment\u00d7time<\/jats:sub>&lt; 0.001). Cummulative urinary and sodium output was significantly less in the uni-x compared with the sham sheep (both, P<jats:sub>treatment\u00d7time<\/jats:sub>&lt; 0.001). GFR was increased in the sham but not the uni-x sheep ( P<jats:sub>treatment\u00d7time<\/jats:sub>&lt; 0.0001). In conclusion, the excretory response to furosemide was attenuated in the uni-x sheep, and this suggests a rightward resetting of the TGF operating point. The TGF mechanism is important in the fine tuning of sodium homeostasis and is likely a contributing factor for the dysfunction in sodium regulation we have previously observed in the uni-x animals.<\/jats:p>","DOI":"10.1152\/ajpregu.00579.2011","type":"journal-article","created":{"date-parts":[[2012,2,9]],"date-time":"2012-02-09T11:44:37Z","timestamp":1328787877000},"page":"R868-R875","source":"Crossref","is-referenced-by-count":4,"title":["Renal responses to furosemide are significantly attenuated in male sheep at 6 months of age following fetal uninephrectomy"],"prefix":"10.1152","volume":"302","author":[{"given":"Reetu R.","family":"Singh","sequence":"first","affiliation":[{"name":"Department of Anatomy and Developmental Biology and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karen M.","family":"Moritz","sequence":"additional","affiliation":[{"name":"School of Biomedical Sciences, University of Queensland, St. Lucia, 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