{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T14:30:44Z","timestamp":1780497044750,"version":"3.54.1"},"reference-count":34,"publisher":"American Physiological Society","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Regulatory, Integrative and Comparative Physiology"],"published-print":{"date-parts":[[2012,10,15]]},"abstract":"<jats:p>We examined whether carbohydrate in beverages accelerated fluid retention during recovery from thermal and exercise-induced dehydration and whether it was caused in part by an enhanced renal Na<jats:sup>+<\/jats:sup>reabsorption rate due to insulin secretion. After dehydrating by \u223c2.3% body weight by exercise in a hot environment, seven young men underwent high-carbohydrate, low-carbohydrate, or control rehydration trials by drinking one of three beverages with 3.4 g glucose + 3.1 g fructose, 1.7 g glucose + 1.6 g fructose, or 0.0 g glucose + 0.0 g fructose per deciliter, respectively, in a common composition of electrolyte solution: 21 meq\/l [Na<jats:sup>+<\/jats:sup>], 5 meq\/l [K<jats:sup>+<\/jats:sup>], 16.5 meq\/l [Cl<jats:sup>\u2212<\/jats:sup>], 10 meq\/l [citrate<jats:sup>\u22123<\/jats:sup>]. They drank the same amount of beverage as total body weight loss within 30 min. During the 60 min before the start of drinking and the following 180 min, we measured plasma volume (PV), plasma glucose ([Glc]<jats:sub>p<\/jats:sub>), serum insulin ([Ins]<jats:sub>s<\/jats:sub>), plasma Na<jats:sup>+<\/jats:sup>concentrations, and the renal clearances of inulin, lithium, and Na<jats:sup>+<\/jats:sup>with plasma vasopressin ([AVP]<jats:sub>p<\/jats:sub>) and aldosterone concentrations ([Ald]<jats:sub>p<\/jats:sub>) every 30 min. After dehydration, PV decreased by \u223c5% and plasma osmolality increased by \u223c6 mosmol\/kgH<jats:sub>2<\/jats:sub>O in all trials with no significant differences among them. We found in the high-carbohydrate trial that 1) PV increased faster than in the control trial and remained at the higher level than other trials for the last 60 min ( P &lt; 0.05); 2) accumulated urine volume was smallest after 90 min ( P &lt; 0.05); 3) the renal Na<jats:sup>+<\/jats:sup>reabsorption rate was greatest for the first 120 min ( P &lt; 0.05); 4) during which period [AVP]<jats:sub>p<\/jats:sub>and [Ald]<jats:sub>p<\/jats:sub>were not significantly different from other trials (both, P &gt; 0.9); and 5) [Glc]<jats:sub>p<\/jats:sub>and [Ins]<jats:sub>s<\/jats:sub>were highest from 45 to 105 min ( P &lt; 0.05) during rehydration. Thus carbohydrate in beverages enhances renal Na<jats:sup>+<\/jats:sup>reabsorption, and insulin is possibly involved in this enhancement.<\/jats:p>","DOI":"10.1152\/ajpregu.00588.2011","type":"journal-article","created":{"date-parts":[[2012,8,9]],"date-time":"2012-08-09T06:19:56Z","timestamp":1344493196000},"page":"R824-R833","source":"Crossref","is-referenced-by-count":32,"title":["Enhanced renal Na<sup>+<\/sup>reabsorption by carbohydrate in beverages during restitution from thermal and exercise-induced dehydration in men"],"prefix":"10.1152","volume":"303","author":[{"given":"Yoshi-ichiro","family":"Kamijo","sequence":"first","affiliation":[{"name":"Department of Sports Medical Sciences, Institute of Pathogenesis and Disease Prevention, Shinshu University Graduate School of Medicine, Matsumoto, Japan; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeki","family":"Ikegawa","sequence":"additional","affiliation":[{"name":"Department of Sports Medical Sciences, Institute of Pathogenesis and Disease Prevention, Shinshu University Graduate School of Medicine, Matsumoto, Japan; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiyuki","family":"Okada","sequence":"additional","affiliation":[{"name":"Department of Sports Medical Sciences, Institute of Pathogenesis and Disease Prevention, Shinshu University Graduate School of Medicine, Matsumoto, Japan; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shizue","family":"Masuki","sequence":"additional","affiliation":[{"name":"Department of Sports Medical Sciences, Institute of Pathogenesis and Disease Prevention, Shinshu University Graduate School of Medicine, Matsumoto, Japan; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazunobu","family":"Okazaki","sequence":"additional","affiliation":[{"name":"Department of Sports Medical Sciences, Institute of Pathogenesis and Disease Prevention, Shinshu University Graduate School of Medicine, Matsumoto, Japan; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koji","family":"Uchida","sequence":"additional","affiliation":[{"name":"Department of Sports Medical Sciences, Institute of Pathogenesis and Disease Prevention, Shinshu University Graduate School of Medicine, Matsumoto, Japan; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masao","family":"Sakurai","sequence":"additional","affiliation":[{"name":"Saga Nutraceuticals Research Institute, Otsuka Pharmaceutical, Kanzaki, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Nose","sequence":"additional","affiliation":[{"name":"Department of Sports Medical Sciences, Institute of Pathogenesis and Disease Prevention, Shinshu University Graduate School of Medicine, Matsumoto, Japan; and"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","first-page":"33","volume-title":"Physiology of Man in the Desert","author":"Adolph EF","year":"1947"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1978.58.3.582"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00197.2009"},{"key":"B4","first-page":"1209","volume":"20","author":"Bangham DR","year":"1959","journal-title":"Bull World Health Organ"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1172\/JCI112925"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1007\/BF00583761"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.1989.257.4.F580"},{"key":"B8","volume-title":"Statistical Power Analysis for the Behavioral Sciences","author":"Cohen J","year":"1988"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1172\/JCI107996"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1172\/JCI108463"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.1994.267.1.F55"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.1992.263.1.F175"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1995.sp020955"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1172\/JCI107983"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1991.71.6.2518"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1979.47.5.1031"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.1994.267.2.F265"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-291X(86)80463-6"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00365.2001"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1989.153"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1016\/B978-012088488-9.50016-4"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.1993.265.3.F361"},{"key":"B23","volume-title":"Study Circle for Health and Nutrition Information. 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