{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T05:09:54Z","timestamp":1697432994613},"reference-count":59,"publisher":"American Physiological Society","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Regulatory, Integrative and Comparative Physiology"],"published-print":{"date-parts":[[2008,7]]},"abstract":"<jats:p>The brain renin-angiotensin system plays an important role in the regulation of arterial pressure in response to stress, in part due to activation of AT<jats:sub>1<\/jats:sub>receptors in the hypothalamic median preoptic nucleus (MnPO) by endogenous angiotensin II (ANG II). N-methyl-d-aspartate (NMDA) receptors are also involved in the angiotensinergic signaling pathway through the MnPO. We investigated whether AT<jats:sub>1<\/jats:sub>and NMDA receptors in the MnPO are responsible for variable hemodynamic response patterns to stress. Cocaine or startle with cold water evoked a pressor response in Sprague-Dawley rats due, in some rats [vascular responders (VR)], to a large increase in systemic vascular resistance (SVR) and, in other rats [mixed responders (MR)], to small increases in SVR and cardiac output (CO). Microinjection of the GABA<jats:sub>A<\/jats:sub>agonist muscimol into the MnPO to block synaptic transmission attenuated the cocaine- or stress-induced increase in SVR and the decrease in CO seen in VR without altering either response in MR. Likewise, administration of either an AT<jats:sub>1<\/jats:sub>receptor antagonist, losartan, or an NMDA receptor antagonist, MK-801, attenuated the increase in SVR and the decrease in CO in VR in response to either cocaine (losartan and MK-801) or startle with cold water (losartan) without altering either response in MR. We propose that the MnPO is responsible for greater SVR responses in VR and that AT<jats:sub>1<\/jats:sub>and NMDA receptors play an important role in greater SVR responses in VR. These data provide additional support for the critical role of the MnPO in cardiovascular responses to stress.<\/jats:p>","DOI":"10.1152\/ajpregu.00606.2007","type":"journal-article","created":{"date-parts":[[2008,4,24]],"date-time":"2008-04-24T00:54:22Z","timestamp":1208998462000},"page":"R155-R165","source":"Crossref","is-referenced-by-count":8,"title":["Angiotensin and NMDA receptors in the median preoptic nucleus mediate hemodynamic response patterns to stress"],"prefix":"10.1152","volume":"295","author":[{"given":"Julie A.","family":"Schwartz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nichole S.","family":"Reilly","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark M.","family":"Knuepfer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","reference":[{"key":"R1","unstructured":"Branch CA, Knuepfer M.Causes of differential cardiovascular sensitivity to cocaine. 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