{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T17:18:10Z","timestamp":1715534290995},"reference-count":31,"publisher":"American Physiological Society","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Regulatory, Integrative and Comparative Physiology"],"published-print":{"date-parts":[[2002,11,1]]},"abstract":"<jats:p>The present work aimed to assess, in Lyon hypertensive (LH) rats, whether an early and prolonged inhibition of the renin-angiotensin system (RAS) could result in a blood pressure (BP) lowering and nephroprotection that persist after its withdrawal. Male LH rats received orally from 3 to 12 wk of age either an angiotensin-converting enzyme inhibitor perindopril at the doses of 0.4 and 3 mg \u00b7 kg<jats:sup>\u22121<\/jats:sup>\u00b7 day<jats:sup>\u22121<\/jats:sup>or an AT<jats:sub>1<\/jats:sub>receptor antagonist losartan at the dose of 10 mg \u00b7 kg<jats:sup>\u22121<\/jats:sup>\u00b7 day<jats:sup>\u22121<\/jats:sup>. BP, histological changes in the kidney, and urinary protein excretion were examined during and 10 wk after cessation of the treatments. Both perindopril and losartan decreased BP, prevented renal lesions, and limited urinary protein excretion. After cessation of the treatment, BP returned to the level of never-treated LH rats in rats having received 3 mg \u00b7 kg<jats:sup>\u22121<\/jats:sup>\u00b7 day<jats:sup>\u22121<\/jats:sup>of perindopril while it remained slightly lower in those treated with 0.4 mg \u00b7 kg<jats:sup>\u22121<\/jats:sup>\u00b7 day<jats:sup>\u22121<\/jats:sup>of perindopril or with losartan. This lack of marked persistent antihypertensive effect contrasted with a durable decrease in urinary protein excretion and improvement of the renal histological lesions. In conclusion, it is possible to separate the BP-lowering effects of RAS blockade from those on glomerulosclerosis and urinary protein excretion.<\/jats:p>","DOI":"10.1152\/ajpregu.00620.2001","type":"journal-article","created":{"date-parts":[[2015,3,3]],"date-time":"2015-03-03T20:26:18Z","timestamp":1425414378000},"page":"R1041-R1045","source":"Crossref","is-referenced-by-count":8,"title":["Differential evolution of blood pressure and renal lesions after RAS blockade in Lyon hypertensive rats"],"prefix":"10.1152","volume":"283","author":[{"given":"Delphine","family":"Bertram","sequence":"first","affiliation":[{"name":"D\u00e9partement de Physiologie et Pharmacologie Clinique, Centre National de la Recherche Scientifique Unit\u00e9 Mixte de Recherche 5014, Institut F\u00e9d\u00e9ratif de Recherche 39, Facult\u00e9 de Pharmacie, 69373 Lyon Cedex 08; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nelly","family":"Blanc-Brunat","sequence":"additional","affiliation":[{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale Unit\u00e9 80, H\u00f4pital Edouard Herriot, 69437 Lyon Cedex 03, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean","family":"Sassard","sequence":"additional","affiliation":[{"name":"D\u00e9partement de Physiologie et Pharmacologie Clinique, Centre National de la Recherche Scientifique Unit\u00e9 Mixte de Recherche 5014, Institut F\u00e9d\u00e9ratif de Recherche 39, Facult\u00e9 de Pharmacie, 69373 Lyon Cedex 08; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming","family":"Lo","sequence":"additional","affiliation":[{"name":"D\u00e9partement de Physiologie et Pharmacologie Clinique, Centre National de la Recherche Scientifique Unit\u00e9 Mixte de Recherche 5014, Institut F\u00e9d\u00e9ratif de Recherche 39, Facult\u00e9 de Pharmacie, 69373 Lyon Cedex 08; and"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.1996.271.5.R1199"},{"key":"B2","first-page":"145","volume":"6","author":"Blanc-Brunat N","year":"1980","journal-title":"Paroi Art\u00e9rielle\/Arterial Wall"},{"key":"B3","first-page":"S27","volume":"6","author":"Christensen HRL","year":"1988","journal-title":"J Hypertens"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1097\/00004872-198902000-00002"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.1997.273.1.F104"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.2001.280.4.R1076"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1097\/00005344-199904000-00006"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1983.tb10726.x"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.2000.279.3.R1099"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1016\/0010-4825(90)90006-B"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1126\/science.2063193"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1681.1986.tb02379.x"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.16.6.603"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.25.1.82"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.1997.273.5.R1793"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.1996.271.2.R346"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.1991.261.4.R1052"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1097\/00004872-199107000-00002"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1097\/00004872-200018090-00011"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1097\/00004872-199307000-00006"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.1998.274.6.R1797"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1097\/00005344-199110000-00021"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.31.6.876"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.28.3.464"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.23.5.659"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1097\/00005344-198603000-00009"},{"key":"B27","first-page":"103","volume":"50","author":"Vincent M","year":"1976","journal-title":"Clin Sci Mol Med"},{"key":"B29","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1093\/clinchem\/32.8.1551","volume":"32","author":"Watanabe N","year":"1986","journal-title":"Clin Chem"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1152\/physiolgenomics.2000.4.1.35"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.22.2.139"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1989.239"}],"container-title":["American Journal of Physiology-Regulatory, Integrative and Comparative Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/ajpregu.00620.2001","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,8,30]],"date-time":"2020-08-30T13:33:06Z","timestamp":1598794386000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/ajpregu.00620.2001"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,11,1]]},"references-count":31,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2002,11,1]]}},"alternative-id":["10.1152\/ajpregu.00620.2001"],"URL":"https:\/\/doi.org\/10.1152\/ajpregu.00620.2001","relation":{},"ISSN":["0363-6119","1522-1490"],"issn-type":[{"value":"0363-6119","type":"print"},{"value":"1522-1490","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,11,1]]}}}