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In the present study, the gracile nucleus was targeted as one of the likely sources of low-threshold information from the penis to MRF. Both electrophysiological recordings and neuroanatomical tracing [injection of cholera toxin B subunit (CTB) into a dorsal nerve of the penis] were used. After discrimination of a single neuron responding to penile stimulation, testing for somatovisceral convergence was done (mechanical stimulation of the distal colon and the skin over the entire hindquarters). In 12 rats, a limited number of neurons (43 in total) responded to penile stimulation. Many of these neurons also responded to scrotal stimulation (53.5%, dorsal and\/or ventral scrotum) and\/or prepuce stimulation (46.5%). Histological reconstruction of the electrode tracks showed that the majority of neurons responding to penile stimulation were located ventrally within the medial one-third of the gracile nucleus surrounding obex. This location corresponded to sparse innervation by CTB-immunoreactive primary afferent terminals. These results indicate that neurons in the gracile nucleus are likely part of the pathway that provides low-threshold penile inputs to MRF, a region known to play an important role in mating processes. <\/jats:p>","DOI":"10.1152\/ajpregu.00656.2007","type":"journal-article","created":{"date-parts":[[2008,1,2]],"date-time":"2008-01-02T20:56:17Z","timestamp":1199307377000},"page":"R1015-R1023","source":"Crossref","is-referenced-by-count":5,"title":["Identification of penile inputs to the rat gracile nucleus"],"prefix":"10.1152","volume":"294","author":[{"given":"Kyle J.","family":"Cothron","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James M.","family":"Massey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen M.","family":"Onifer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles H.","family":"Hubscher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","reference":[{"key":"R1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1996.76.4.2661"},{"key":"R2","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1997.78.1.521"},{"key":"R3","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2004.21.1371"},{"key":"R4","doi-asserted-by":"publisher","DOI":"10.1038\/sj.sc.3101978"},{"key":"R5","doi-asserted-by":"publisher","DOI":"10.1016\/0013-4694(82)90034-7"},{"key":"R6","doi-asserted-by":"publisher","DOI":"10.1038\/nm0895-766"},{"key":"R6A","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1993.69.2.545"},{"key":"R7","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(01)63200-2"},{"key":"R8","doi-asserted-by":"publisher","DOI":"10.1093\/ptj\/76.11.1221"},{"key":"R9","doi-asserted-by":"publisher","DOI":"10.1080\/08990229870844"},{"key":"R10","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902630106"},{"key":"R11","doi-asserted-by":"publisher","DOI":"10.1038\/sj.sc.3101880"},{"key":"R12","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3940(99)00599-6"},{"key":"R13","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(85)90044-7"},{"key":"R14","doi-asserted-by":"publisher","DOI":"10.1002\/cne.903160206"},{"key":"R15","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1982.00510170022006"},{"key":"R16","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2006.02.008"},{"key":"R17","doi-asserted-by":"publisher","DOI":"10.1016\/S0079-6123(05)52027-2"},{"key":"R18","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(94)91946-1"},{"key":"R19","doi-asserted-by":"publisher","DOI":"10.1097\/01.wnr.0000128428.74337.ef"},{"key":"R20","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1996.76.4.2474"},{"key":"R21","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1999.82.3.1381"},{"key":"R22","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00294.2002"},{"key":"R23","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00310.2004"},{"key":"R24","doi-asserted-by":"publisher","DOI":"10.1002\/cne.903120212"},{"key":"R25","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902420105"},{"key":"R26","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2005.102574"},{"key":"R26A","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(94)90054-X"},{"key":"R27","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4886(82)90021-8"},{"key":"R28","doi-asserted-by":"publisher","DOI":"10.1002\/cne.903110409"},{"key":"R29","doi-asserted-by":"publisher","DOI":"10.1016\/0168-5597(93)90033-L"},{"key":"R30","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.10078"},{"key":"R31","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(91)91351-Z"},{"key":"R32","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(92)90378-M"},{"key":"R33","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5467-05.2006"},{"key":"R34","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2007.07.012"},{"key":"R35","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/109.5.1003"},{"key":"R36","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901300406"},{"key":"R37","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4886(77)90049-8"},{"key":"R38","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2007.06.012"},{"key":"R39","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2004.10.016"},{"key":"R40","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(97)00408-3"},{"key":"R41","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(90)90697-8"},{"key":"R42","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902900307"},{"key":"R43","unstructured":"Paxinos G, Watson C. 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