{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T17:15:44Z","timestamp":1789665344687,"version":"4.0.1"},"reference-count":42,"publisher":"American Physiological Society","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Regulatory, Integrative and Comparative Physiology"],"published-print":{"date-parts":[[2007,6]]},"abstract":"<jats:p>\n                    This study reports for the first time the effects of retinoid-related orphan receptors [ROR\u03b2; receptor gene deletion ROR\u03b2(C3H)\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    ] in C3H\/HeN mice on behavioral and circadian phenotypes. Pineal melatonin levels showed a robust diurnal rhythm with high levels at night in wild-type (+\/+), heterozygous (+\/\u2212), and knockout (\u2212\/\u2212) mice. The ROR\u03b2(C3H)\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    mice displayed motor (\u201cduck gait,\u201d hind paw clasping reflex) and olfactory deficits, and reduced anxiety and learned helplessness-related behaviors. Circadian rhythms of wheel-running activity in all genotypes showed entrainment to the light-dark (LD) cycle, and free running in constant dark, with ROR\u03b2(C3H)\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    mice showing a significant increase in circadian period ( tau). Melatonin administration (90 \u03bcg\/mouse sc for 3 days) at circadian time (CT) 10 induced phase advances, while exposure to a light pulse (300 lux) at CT 14 induced phase delays of circadian activity rhythms of the same magnitude in all genotypes. In ROR\u03b2(C3H)\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    mice a light pulse at CT 22 elicited a larger phase advance in activity rhythms and a slower rate of reentrainment after a 6-h advance in the LD cycle compared with (+\/+) mice. Yet, the rate of reentrainment was significantly advanced by melatonin administration at the new dark onset in both (+\/+) and (\u2212\/\u2212) mice. We conclude that the ROR\u03b2 nuclear receptor is not involved in either the rhythmic production of pineal melatonin or in mediating phase shifts of circadian rhythms by melatonin, but it may regulate clock responses to photic stimuli at certain time domains.\n                  <\/jats:p>","DOI":"10.1152\/ajpregu.00687.2006","type":"journal-article","created":{"date-parts":[[2007,2,15]],"date-time":"2007-02-15T20:46:41Z","timestamp":1171572401000},"page":"R2357-R2367","source":"Crossref","is-referenced-by-count":61,"title":["Behavioral characterization and modulation of circadian rhythms by light and melatonin in C3H\/HeN mice homozygous for the ROR\u03b2 knockout"],"prefix":"10.1152","volume":"292","author":[{"given":"Monica I.","family":"Masana","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel C.","family":"Sumaya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Becker-Andre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margarita L.","family":"Dubocovich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"R1","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/17.14.3867"},{"key":"R2","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-1119(98)00348-5"},{"key":"R3","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1996.0517"},{"key":"#cr-split#-R4.1","doi-asserted-by":"crossref","unstructured":"Becker-Andre M, Wiesenberg I, Schaeren-Wiemers N, Andre E, Missbach M, Saurat JH, Carlberg C. Pineal gland hormone melatonin binds and activates an orphan of the nuclear receptor superfamily [published erratum appears in J Biol Chem 1997 Jun 27","DOI":"10.1074\/jbc.272.26.16707"},{"key":"#cr-split#-R4.2","doi-asserted-by":"crossref","unstructured":"272: 16707] J Biol Chem 269: 28531-28534, 1994.","DOI":"10.1016\/S0021-9258(19)61934-4"},{"key":"R5","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(96)01182-1"},{"key":"R6","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.22-22-10046.2002"},{"key":"R7","doi-asserted-by":"crossref","unstructured":"Carlberg C\n                      , Hooft van Huijsduijnen R, Staple JK, DeLamarter JF, and Becker-Andre M.\n                      RZRs, a new family of retinoid-related orphan receptors that function as both monomers and homodimers.\n                      Mol Endocrinol\n                      8\n                      : 757\u2013770, 1994.","DOI":"10.1210\/mend.8.6.7935491"},{"key":"R8","doi-asserted-by":"crossref","unstructured":"Crawley JN\n                      .\n                      What is wrong with my mouse?\n                      Behavioral phenotyping of transgenic and knockout mice.\n                      New York: Wiley, 2000.","DOI":"10.1201\/9781420048384.pt3"},{"key":"R9","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-079X.2005.00230.x"},{"key":"R10","doi-asserted-by":"publisher","DOI":"10.1385\/ENDO:27:2:101"},{"key":"R11","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.19-21-09550.1999"},{"key":"R12","doi-asserted-by":"publisher","DOI":"10.1034\/j.1601-183X.2003.00002.x"},{"key":"R13","doi-asserted-by":"publisher","DOI":"10.1177\/074873049300800102"},{"key":"R14","doi-asserted-by":"publisher","DOI":"10.1159\/000076629"},{"key":"R15","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.19.10105"},{"key":"R16","doi-asserted-by":"publisher","DOI":"10.1038\/nrn1177"},{"key":"R17","doi-asserted-by":"publisher","DOI":"10.1126\/science.1069609"},{"key":"R18","doi-asserted-by":"publisher","DOI":"10.1038\/nature01761"},{"key":"R19","unstructured":"Hudson RL\n                      , Ginter P, Stepien I, Dubocovich ML.\n                      Distinct melatonin receptors are involved in melatonin (MLT)-mediated phase shifts of circadian rhythms of wheel running activity in vivo and of neuronal firing in the suprachiasmatic nucleus (SCN) brain slice\n                      [Online]. 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Society for Neuroscience."},{"key":"R20","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.2001.280.1.C110"},{"key":"R21","doi-asserted-by":"publisher","DOI":"10.1016\/S0079-6603(01)69048-2"},{"key":"R22","doi-asserted-by":"publisher","DOI":"10.1177\/002215540205001209"},{"key":"R23","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)80350-5"},{"key":"R24","doi-asserted-by":"publisher","DOI":"10.1016\/0166-2236(95)98376-A"},{"key":"R25","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(01)00401-9"},{"key":"R26","doi-asserted-by":"publisher","DOI":"10.1159\/000072271"},{"key":"R27","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(96)01320-0"},{"key":"R28","unstructured":"Porsolt RD\n                      , Bertin A, Jalfre M.\n                      Behavioral despair in mice: a primary screening test for antidepressants.\n                      Arch Int Pharmacodyn Ther\n                      229\n                      : 327\u2013336, 1977."},{"key":"R29","doi-asserted-by":"publisher","DOI":"10.1177\/074873049200700107"},{"key":"R30","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-9384(96)00515-X"},{"key":"R31","doi-asserted-by":"publisher","DOI":"10.1210\/endo.142.11.8464"},{"key":"R32","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2004.07.018"},{"key":"R33","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.1997.tb01698.x"},{"key":"R34","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.10-11-03685.1990"},{"key":"R35","doi-asserted-by":"publisher","DOI":"10.1007\/BF02981700"},{"key":"R36","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2826.2000.00479.x"},{"key":"R37","doi-asserted-by":"publisher","DOI":"10.1038\/nsb979"},{"key":"R38","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3940(02)00011-3"},{"key":"R39","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.270.34.20156"},{"key":"R40","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-079X.1993.tb00514.x"},{"key":"R41","doi-asserted-by":"publisher","DOI":"10.1002\/syn.20067"}],"container-title":["American Journal of Physiology-Regulatory, Integrative and Comparative Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/ajpregu.00687.2006","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,8]],"date-time":"2021-08-08T16:33:12Z","timestamp":1628440392000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/ajpregu.00687.2006"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,6]]},"references-count":42,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2007,6]]}},"alternative-id":["10.1152\/ajpregu.00687.2006"],"URL":"https:\/\/doi.org\/10.1152\/ajpregu.00687.2006","relation":{},"ISSN":["0363-6119","1522-1490"],"issn-type":[{"value":"0363-6119","type":"print"},{"value":"1522-1490","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,6]]}}}