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Rectal discomfort thresholds were measured using a randomized, phasic distension paradigm before and after repeated noxious sigmoid stimulation (SIG, 60-mmHg pulses). Sex had a significant effect on rectal discomfort thresholds. Women with IBS were the most sensitive (lower thresholds [27 \u00b1 2.7 mmHg] and higher ratings), with significantly lower rectal discomfort thresholds compared with men with IBS (38 \u00b1 2.3 mmHg) and healthy women who were the least sensitive (41.9 \u00b1 3.2 mmHg; both P &lt; 0.01). There were no significant differences in rectal discomfort thresholds between healthy men (34 \u00b1 4.3 mmHg) and men with IBS. Across both IBS and control groups, women demonstrated a significant lowering of discomfort thresholds after noxious sigmoid stimulation ( P &lt; 0.01), while men did not. Sex significantly influences perceptual sensitivity to rectosigmoid distension. 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