{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T23:39:18Z","timestamp":1767829158986,"version":"3.49.0"},"reference-count":60,"publisher":"American Physiological Society","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Regulatory, Integrative and Comparative Physiology"],"published-print":{"date-parts":[[2002,6,1]]},"abstract":"<jats:p>To better understand the biology of leptin during prenatal life, the developmental and spatial regulation of leptin was studied in ovine fetuses. Fetal plasma leptin increased steadily between days 40 and 143 postcoitus (PC), but it was unrelated to fetal weight or placental weight at day 135 PC. Leptin gene expression was detected in fetal brain and liver during most of gestation and in fetal adipose tissue after day 100 PC. At day 130 PC, expression in fetal perirenal adipose tissue was \u223c10% of maternal expression. In contrast, leptin gene expression was never detected in the placenta and other uteroplacental tissues. When ewes were fed 55% of requirements between days 122 and 135 PC, fetal plasma leptin remained constant despite acute reduction in maternal concentration. We conclude that fetal plasma leptin originates mostly from nonadipose tissue in early pregnancy and, in addition, from fetal adipose tissue near term. The role of fetal plasma leptin remains uncertain given the lack of nutritional regulation and association with fetal growth.<\/jats:p>","DOI":"10.1152\/ajpregu.00750.2001","type":"journal-article","created":{"date-parts":[[2015,3,3]],"date-time":"2015-03-03T20:24:08Z","timestamp":1425414248000},"page":"R1628-R1635","source":"Crossref","is-referenced-by-count":41,"title":["Spatial and developmental regulation of leptin in fetal sheep"],"prefix":"10.1152","volume":"282","author":[{"given":"Richard A.","family":"Ehrhardt","sequence":"first","affiliation":[{"name":"Department of Animal Science, Cornell University, Ithaca, New York 14853"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alan W.","family":"Bell","sequence":"additional","affiliation":[{"name":"Department of Animal Science, Cornell University, Ithaca, New York 14853"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yves R.","family":"Boisclair","sequence":"additional","affiliation":[{"name":"Department of Animal Science, Cornell University, Ithaca, New York 14853"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1210\/endo.140.6.6774"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.physiol.62.1.413"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1038\/382250a0"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1071\/BI9780489"},{"key":"B5","first-page":"401","volume":"54","author":"Bell AW","year":"1999","journal-title":"J Reprod Fertil Suppl"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-9822(02)70684-2"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1677\/joe.0.1650625"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1677\/joe.0.1710339"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.1998.275.6.E1082"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2001.117313"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(95)90478-6"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1177\/107155769800500604"},{"key":"B13","first-page":"97","volume":"4","author":"Dick AT.","year":"1956","journal-title":"J Embryol Exp Morphol"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1016\/S0739-7240(97)00028-3"},{"key":"B15","first-page":"955","volume":"42","author":"Efstratiadis A.","year":"1998","journal-title":"Int J Dev Biol"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1016\/0143-4004(95)90016-0"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1016\/S0739-7240(01)00108-4"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1677\/joe.0.1660519"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod62.3.698"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.48.30546"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2265.1999.00758.x"},{"key":"B22","first-page":"10","volume":"51","author":"Gomez L","year":"1999","journal-title":"Horm Res"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.82.10.4321"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1542\/peds.100.1.e1"},{"key":"B25","first-page":"2543","volume":"84","author":"Henson MC","year":"1999","journal-title":"J Clin Endocrinol Metab"},{"key":"B26","first-page":"1020","volume":"92","author":"Henson MC","year":"1998","journal-title":"Obstet Gynecol"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1159\/000014286"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1042\/bst0290057"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.20.11073"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114500000398"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1007\/s001250051367"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ijo.0801370"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ijo.0801563"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.83.4.4731"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1177\/107155760100800206"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1210\/edrv.22.1.0419"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.47.5.847"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.86.6.7529"},{"key":"B39","first-page":"4298","volume":"85","author":"Linnemann K","year":"2000","journal-title":"J Clin Endocrinol Metab"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-978936"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1677\/joe.0.1700277"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1038\/nm0997-1029"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.2527\/1997.753809x"},{"key":"B44","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.1182\/blood.V89.5.1507","volume":"89","author":"Mikhail AA","year":"1997","journal-title":"Blood"},{"key":"B45","first-page":"3225","volume":"83","author":"Mise H","year":"1998","journal-title":"J Clin Endocrinol Metab"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1210\/endo.140.12.7288"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1210\/endo.139.12.6523"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-978776"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/123.7.1286"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1042\/bst0290068"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1007\/s004670000351"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1017\/S0021859600024874"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1016\/S0739-7240(96)00090-2"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.82.5.3935"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1126\/science.281.5383.1683"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(01)00240-9"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1002\/ar.1091850206"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1677\/joe.0.1690465"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.2000.279.6.E1294"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00392.2001"}],"container-title":["American Journal of Physiology-Regulatory, Integrative and Comparative Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/ajpregu.00750.2001","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,8,30]],"date-time":"2020-08-30T13:32:37Z","timestamp":1598794357000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/ajpregu.00750.2001"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,6,1]]},"references-count":60,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2002,6,1]]}},"alternative-id":["10.1152\/ajpregu.00750.2001"],"URL":"https:\/\/doi.org\/10.1152\/ajpregu.00750.2001","relation":{},"ISSN":["0363-6119","1522-1490"],"issn-type":[{"value":"0363-6119","type":"print"},{"value":"1522-1490","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,6,1]]}}}