{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T00:43:20Z","timestamp":1776732200258,"version":"3.51.2"},"reference-count":47,"publisher":"American Physiological Society","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Regulatory, Integrative and Comparative Physiology"],"published-print":{"date-parts":[[2007,6]]},"abstract":"<jats:p>\n                    Chronic exposure to intermittent hypoxia (CIH) has been used in animals to mimic the arterial hypoxemia that accompanies sleep apnea. Humans with sleep apnea and animals exposed to CIH have elevated blood pressures and augmented sympathetic nervous system responses to acute exposures to hypoxia. To test the hypothesis that exposure to CIH alters neurons within the nucleus of the solitary tract (NTS) that integrate arterial chemoreceptor afferent inputs, we measured whole cell currents induced by activation of \u03b1-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA) and N-methyl-d-aspartate (NMDA) receptors in enzymatically dispersed NTS neurons from normoxic (NORM) and CIH-exposed rats (alternating cycles of 3 min at 10% O\n                    <jats:sub>2<\/jats:sub>\n                    followed by 3 min at 21% O\n                    <jats:sub>2<\/jats:sub>\n                    between 8 AM and 4 PM for 7 days). To identify NTS neurons receiving carotid body afferent inputs the anterograde tracer 4- (4-(dihexadecylamino)styryl- N-methylpyridinum iodide (DiA) was placed onto the carotid body 1 wk before exposure to CIH. AMPA dose-response curves had similar EC\n                    <jats:sub>50<\/jats:sub>\n                    but maximal responses increased in neurons isolated from DiA-labeled CIH (20.1 \u00b1 0.8 \u03bcM, n = 9) compared with NORM (6.0 \u00b1 0.3 \u03bcM, n = 8) rats. NMDA dose-response curves also had similar EC\n                    <jats:sub>50<\/jats:sub>\n                    but maximal responses decreased in CIH (8.4 \u00b1 0.4 \u03bcM, n = 8) compared with NORM (19.4 \u00b1 0.6 \u03bcM, n = 9) rats. These results suggest reciprocal changes in the number and\/or conductance characteristics of AMPA and NMDA receptors. Enhanced responses to AMPA receptor activation could contribute to enhanced chemoreflex responses observed in animals exposed to CIH and humans with sleep apnea.\n                  <\/jats:p>","DOI":"10.1152\/ajpregu.00760.2006","type":"journal-article","created":{"date-parts":[[2007,3,1]],"date-time":"2007-03-01T23:13:51Z","timestamp":1172790831000},"page":"R2259-R2265","source":"Crossref","is-referenced-by-count":65,"title":["Chronic intermittent hypoxia alters NMDA and AMPA-evoked currents in NTS neurons receiving carotid body chemoreceptor inputs"],"prefix":"10.1152","volume":"292","author":[{"given":"Patricia M.","family":"de Paula","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gleb","family":"Tolstykh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steve","family":"Mifflin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","reference":[{"key":"R1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.39.25132"},{"key":"R2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(02)03693-4"},{"key":"R3","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1997.83.1.95"},{"key":"R4","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2006.06.013"},{"key":"R5","doi-asserted-by":"publisher","DOI":"10.1042\/BST0331354"},{"key":"R6","doi-asserted-by":"publisher","DOI":"10.1378\/chest.103.6.1763"},{"key":"R7","doi-asserted-by":"publisher","DOI":"10.1023\/A:1007644128886"},{"key":"R8","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1999.87.1.363"},{"key":"R9","doi-asserted-by":"crossref","unstructured":"Dingledine R\n                      , Borges K, Bowie D, Traynelis SF.\n                      The glutamate receptor ion channels.\n                      Pharmacol Rev\n                      51\n                      : 7\u201361, 1999.","DOI":"10.1016\/S0031-6997(24)01394-2"},{"key":"R10","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1992.72.5.1978"},{"key":"R11","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.19.6.555"},{"key":"R12","doi-asserted-by":"publisher","DOI":"10.1016\/S0034-5687(00)00129-8"},{"key":"R13","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3940(99)00065-8"},{"key":"R14","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1998.84.6.1982"},{"key":"R15","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1998.85.1.372"},{"key":"R16","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1999.86.1.298"},{"key":"R17","unstructured":"Guilleminault C\n                      , Suzuki M.\n                      Sleep-related hemodynamics and hypertension with partial or complete upper airway obstruction during sleep.\n                      Sleep\n                      15\n                      : S20\u2013S24, 1992."},{"key":"R18","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-120-5-199403010-00005"},{"key":"R19","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-201X.2003.01083.x"},{"key":"R20","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00224.2002"},{"key":"R21","doi-asserted-by":"publisher","DOI":"10.1046\/j.1460-9568.2003.02494.x"},{"key":"R22","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.1992.263.2.R368"},{"key":"R23","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1994.sp020229"},{"key":"R24","doi-asserted-by":"publisher","DOI":"10.1097\/00004872-199715120-00062"},{"key":"R25","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.97.10.943"},{"key":"R26","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.99.9.1183"},{"key":"R27","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2002.023994"},{"key":"R28","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-2236(02)00004-8"},{"key":"R29","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1734109100"},{"key":"R30","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00820.2003"},{"key":"R31","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00613.2002"},{"key":"R32","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00759.2002"},{"key":"R33","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2004.072033"},{"key":"R34","doi-asserted-by":"publisher","DOI":"10.1113\/eph8802476"},{"key":"R35","doi-asserted-by":"publisher","DOI":"10.1016\/j.molbrainres.2003.11.003"},{"key":"R36","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.21-20-08154.2001"},{"key":"R37","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-4388(97)80063-3"},{"key":"R38","doi-asserted-by":"publisher","DOI":"10.1172\/JCI118235"},{"key":"R39","doi-asserted-by":"publisher","DOI":"10.1007\/s00702-002-0782-8"},{"key":"R40","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2004.01.060"},{"key":"R41","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000084371.17927.02"},{"key":"R42","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.1993.264.1.R41"},{"key":"R43","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.2000.278.2.R520"},{"key":"R44","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199304293281704"},{"key":"R45","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.2109080"},{"key":"R46","doi-asserted-by":"publisher","DOI":"10.1016\/0165-1838(95)00027-U"},{"key":"R47","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1993.265.2.H770"}],"container-title":["American Journal of Physiology-Regulatory, Integrative and Comparative Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/ajpregu.00760.2006","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,14]],"date-time":"2025-01-14T08:00:23Z","timestamp":1736841623000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/ajpregu.00760.2006"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,6]]},"references-count":47,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2007,6]]}},"alternative-id":["10.1152\/ajpregu.00760.2006"],"URL":"https:\/\/doi.org\/10.1152\/ajpregu.00760.2006","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.1090226.543448","asserted-by":"object"}]},"ISSN":["0363-6119","1522-1490"],"issn-type":[{"value":"0363-6119","type":"print"},{"value":"1522-1490","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,6]]}}}