{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T14:17:31Z","timestamp":1791296251500,"version":"4.1.0"},"reference-count":31,"publisher":"American Physiological Society","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Regulatory, Integrative and Comparative Physiology"],"published-print":{"date-parts":[[2007,5]]},"abstract":"<jats:p> We investigated whether LPS-induced hypothermia develops in a serotype-specific manner in biotelemetered conscious rats. Two different Escherichia coli serotypes of LPSs were injected at a dose of 250 \u03bcg\/kg ip. E. coli O55:B5 LPS elicited an initial hypothermia and subsequent fever, but E. coli O111:B4 LPS caused more potent monophasic hypothermia. Serum tumor necrosis factor (TNF)-\u03b1 levels were dramatically elevated at the initial phase of the hypothermia induced by both LPSs. This elevation tended to subside at the nadir of E. coli O55:B5 LPS-induced response but progressively increased at the nadir of E. coli O111:B4 LPS hypothermia. Serum IL-10 levels were moderately elevated at the initial phase of the hypothermia and persisted at the same level at the nadir of each LPS-induced response. No change was observed at the serum IL-18 levels. A selective cyclooxygenase (COX)-1 enzyme inhibitor, valeryl salicylate (20 mg\/kg sc), abolished the hypothermia without any effect on the elevated cytokine levels. Another COX-1-selective inhibitor, 5-(4-chlorophenyl)-1-(4-methoxyphenyl)-3-(trifluoromethyl)-1H-pyrazole (SC-560; 1 mg\/kg sc) inhibited hypothermic responses as well. Meanwhile, cytokine levels were also reduced by SC-560 treatment. These findings suggest that LPS-induced hypothermia may have serotype-specific characteristics in rats. E. coli O111:B4 LPS has more potent hypothermic activity than E. coli O55:B5 LPS; that may presumably be related to its higher or sustained capability to release antipyretic cytokines, such as TNF-\u03b1. COX-1 enzyme may be involved in the generation of the hypothermia, regardless of the type of LPS administered. <\/jats:p>","DOI":"10.1152\/ajpregu.00786.2006","type":"journal-article","created":{"date-parts":[[2007,2,3]],"date-time":"2007-02-03T06:52:19Z","timestamp":1170485539000},"page":"R1846-R1850","source":"Crossref","is-referenced-by-count":43,"title":["<i>Escherichia coli<\/i> lipopolysaccharides produce serotype-specific hypothermic response in biotelemetered rats"],"prefix":"10.1152","volume":"292","author":[{"given":"Eyup S.","family":"Akarsu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soner","family":"Mamuk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"R1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4419-9194-2_28"},{"key":"R2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2006.04854.x"},{"key":"R3","doi-asserted-by":"crossref","unstructured":"DeRijk RH, Van Kampen M, Van Rooijen N, Berkenbosch F. 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