{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T11:28:21Z","timestamp":1775129301865,"version":"3.50.1"},"reference-count":47,"publisher":"American Physiological Society","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Regulatory, Integrative and Comparative Physiology"],"published-print":{"date-parts":[[2010,4]]},"abstract":"<jats:p> Humans with spinal cord injury have impaired cardiovascular function proportional to the level and completeness of the lesion. The effect on cerebrovascular function is unclear, especially for high-level lesions. The purpose of this study was to evaluate the integrity of dynamic cerebral autoregulation (CA) and the cerebrovascular reactivity in chronic tetraplegia (Tetra). After baseline, steady-state hypercapnia (5% CO<jats:sub>2<\/jats:sub>) and hypocapnia (controlled hyperventilation) were used to assess cerebrovascular reactivity in 6 men with Tetra (C5\u2013C7 lesion) and 14 men without [able-bodied (AB)]. Middle cerebral artery blood flow velocity (MCAv), cerebral oxygenation, arterial blood pressure (BP), heart rate (HR), cardiac output (Q\u0307; model flow), partial pressure of end-tidal CO<jats:sub>2<\/jats:sub> (Pet<jats:sub>CO<jats:sub>2<\/jats:sub><\/jats:sub>), and plasma catecholamines were measured. Dynamic CA was assessed by transfer function analysis of spontaneous fluctuations in BP and MCAv. MCAv pulsatility index (MCAv PI) was calculated as (MCAv<jats:sub>systolic<\/jats:sub> \u2212 MCAv<jats:sub>diastolic<\/jats:sub>)\/MCAv<jats:sub>mean<\/jats:sub> and standardized by dividing by mean arterial pressure (MAP). Resting BP, total peripheral resistance, and catecholamines were lower in Tetra ( P &lt; 0.05), and standardized MCAv PI was \u223c36% higher in Tetra ( P = 0.003). Resting MCAv, cerebral oxygenation, HR, and Pet<jats:sub>CO<jats:sub>2<\/jats:sub><\/jats:sub> were similar between groups ( P &gt; 0.05). Although phase and transfer function gain relationships in dynamic CA were maintained with Tetra ( P &gt; 0.05), coherence in the very low-frequency range (0.02\u20130.07 Hz) was \u223c21% lower in Tetra ( P = 0.006). Full (hypo- and hypercapnic) cerebrovascular reactivity to CO<jats:sub>2<\/jats:sub> was unchanged with Tetra ( P &gt; 0.05). During hypercapnia, standardized MCAv PI reactivity was enhanced by \u223c78% in Tetra ( P = 0.016). Despite impaired cardiovascular function, chronic Tetra involves subtle changes in dynamic CA and cerebrovascular reactivity to CO<jats:sub>2<\/jats:sub>. Changes are evident in coherence at baseline and MCAv PI during baseline and hypercapnic states in chronic Tetra, which may be indicative of cerebrovascular adaptation. <\/jats:p>","DOI":"10.1152\/ajpregu.00815.2009","type":"journal-article","created":{"date-parts":[[2010,1,21]],"date-time":"2010-01-21T02:55:06Z","timestamp":1264042506000},"page":"R1035-R1042","source":"Crossref","is-referenced-by-count":21,"title":["Cerebrovascular reactivity and dynamic autoregulation in tetraplegia"],"prefix":"10.1152","volume":"298","author":[{"given":"Luke C.","family":"Wilson","sequence":"first","affiliation":[{"name":"Department of Physiology, Otago School of Medical Science and"},{"name":"School of Physical Education, University of Otago, Dunedin, New Zealand; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James D.","family":"Cotter","sequence":"additional","affiliation":[{"name":"School of Physical Education, University of Otago, Dunedin, New Zealand; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jui-Lin","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Physiology, Otago School of Medical Science and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rebekah A. 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