{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T17:16:01Z","timestamp":1793121361541,"version":"4.5.0"},"reference-count":74,"publisher":"American Physiological Society","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Regulatory, Integrative and Comparative Physiology"],"published-print":{"date-parts":[[2005,11]]},"abstract":"<jats:p>\n                    To determine whether conditions for O\n                    <jats:sub>2<\/jats:sub>\n                    utilization and O\n                    <jats:sub>2<\/jats:sub>\n                    off-loading from the hemoglobin are different in exercising arms and legs, six cross-country skiers participated in this study. Femoral and subclavian vein blood flow and gases were determined during skiing on a treadmill at \u223c76% maximal O\n                    <jats:sub>2<\/jats:sub>\n                    uptake (V\u0307o\n                    <jats:sub>2 max<\/jats:sub>\n                    ) and at V\u0307o\n                    <jats:sub>2 max<\/jats:sub>\n                    with different techniques: diagonal stride (combined arm and leg exercise), double poling (predominantly arm exercise), and leg skiing (predominantly leg exercise). The percentage of O\n                    <jats:sub>2<\/jats:sub>\n                    extraction was always higher for the legs than for the arms. At maximal exercise (diagonal stride), the corresponding mean values were 93 and 85% ( n = 3; P &lt; 0.05). During exercise, mean arm O\n                    <jats:sub>2<\/jats:sub>\n                    extraction correlated with the Po\n                    <jats:sub>2<\/jats:sub>\n                    value that causes hemoglobin to be 50% saturated (P\n                    <jats:sub>50<\/jats:sub>\n                    : r = 0.93, P &lt; 0.05), but for a given value of P\n                    <jats:sub>50<\/jats:sub>\n                    , O\n                    <jats:sub>2<\/jats:sub>\n                    extraction was always higher in the legs than in the arms. Mean capillary muscle O\n                    <jats:sub>2<\/jats:sub>\n                    conductance of the arm during double poling was 14.5 (SD 2.6) ml\u00b7min\n                    <jats:sup>\u22121<\/jats:sup>\n                    \u00b7mmHg\n                    <jats:sup>\u22121<\/jats:sup>\n                    , and mean capillary Po\n                    <jats:sub>2<\/jats:sub>\n                    was 47.7 (SD 2.6) mmHg. Corresponding values for the legs during maximal exercise were 48.3 (SD 13.0) ml\u00b7min\n                    <jats:sup>\u22121<\/jats:sup>\n                    \u00b7mmHg\n                    <jats:sup>\u22121<\/jats:sup>\n                    and 33.8 (SD 2.6) mmHg, respectively. Because conditions for O\n                    <jats:sub>2<\/jats:sub>\n                    off-loading from the hemoglobin are similar in leg and arm muscles, the observed differences in maximal arm and leg O\n                    <jats:sub>2<\/jats:sub>\n                    extraction should be attributed to other factors, such as a higher heterogeneity in blood flow distribution, shorter mean transit time, smaller diffusing area, and larger diffusing distance, in arms than in legs.\n                  <\/jats:p>","DOI":"10.1152\/ajpregu.00824.2004","type":"journal-article","created":{"date-parts":[[2005,5,26]],"date-time":"2005-05-26T20:24:44Z","timestamp":1117139084000},"page":"R1448-R1458","source":"Crossref","is-referenced-by-count":176,"title":["Why do arms extract less oxygen than legs during exercise?"],"prefix":"10.1152","volume":"289","author":[{"given":"J. A. 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